Type I IFN promotes pathogenic inflammatory monocyte maturation during H5N1 infection
S. Fourati, D. Jimenez-Morales, J. F. Hultquist, M. W. Chang, C. Benner, N. J. Krogan, L. Pache, S. Chanda, R.-P. Sekaly, A. Garcia-Sastre, M. B. Uccellini
This study shows that type I IFN promotes the maturation of inflammatory monocytes into pathogenic FasL+MCs during H5N1 infection, contributing to disease severity.
bioRxiv · Jan 10, 2022 · PreprintImmunology