Author

M. Boutros

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

S. Leible· 2 shared A. Cammarata-Mouchtouris· 1 shared A. Goto· 1 shared A. Lambert· 1 shared A. Orian· 1 shared A. Plociennikowska· 1 shared A. Wittmann· 1 shared B. Cerikan· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersCancer Biology

S. Leible

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Restraining Wnt activation and intestinal tumorigenesis by a Rab35 dependent GTPase relay

S. Redhai, T. Eang, K. E. Boonekamp, S. Rueter, T. C. Klemens, S. Leible, S. Bahuguna, F. Port, B. Pavlovic, M. Holzem, R. Doll, N. Rindtorff, E. Valentini, B. Schmitt, K. Richter, , M. Boutros

This study identifies Rab35 as a tumor suppressor that modulates Wnt signaling through a GTPase relay, highlighting its role in restraining intestinal tumorigenesis.

bioRxiv · Feb 5, 2024 · PreprintCancer Biology

EVI/WLS function is regulated by ubiquitination and linked to ER-associated degradation by ERLIN2

L. Wolf, A. Lambert, J. Haenlin, M. Boutros

This study identifies ERLIN2 as a link between ubiquitination and ERAD in regulating EVI/WLS stability, independent of WNT production levels.

bioRxiv · Dec 9, 2020Cell Biology

Establishment of a simplified preparation method for single-nucleus RNA-sequencing and its application to long-term frozen tumor tissues

K. F. Ernst, K. Okonechnikov, J. Bageritz, J.-P. Mallm, A. Wittmann, K. K. Maass, S. Leible, M. Boutros, S. M. Pfister, M. Zuckermann, D. T. W. Jones

The paper develops a simplified method for isolating nuclei from frozen tumor tissues and applies it to analyze pediatric central nervous system tumors using snRNA-seq.

bioRxiv · Oct 23, 2020 · PreprintCancer Biology

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

C. J. Neufeldt, B. Cerikan, M. Cortese, J. Frankish, J.-Y. Lee, A. Plociennikowska, F. Heigwer, S. Joecks, S. S. Burkart, D. Y. Zander, M. Gendarme, B. El Debs, N. Halama, U. Merle, M. Boutros, , R. Bartenschlager

This study shows SARS-CoV-2 triggers a pro-inflammatory cytokine response via cGAS-STING and NF-κB in epithelial cells, which may contribute to severe disease.

bioRxiv · Jul 21, 2020Microbiology

Hyd ubiquitinates the NF-κB co-factor Akirin to activate an effective immune response in Drosophila

A. Cammarata-Mouchtouris, X.-H. Nguyen, F. Bonnay, A. Goto, A. Orian, M.-O. Fauvarque, M. Boutros, J.-M. Reichhart, N. Matt

This study identifies Hyd as an E3-ubiquitin ligase that ubiquitinates Akirin to enhance Relish binding and activate immune effector genes in Drosophila.

bioRxiv · Jul 20, 2018Immunology