S. Russell

A beneficial synonymous substitution in EF-Tu is contingent on genetic background

The paper identifies a beneficial synonymous mutation in EF-Tu that increases mRNA and protein levels but shows fitness benefits dependent on genetic background.

Ecological differences among hydrothermal vent symbioses may drive contrasting patterns of symbiont population differentiation

This study compares symbiont population differentiation in deep-sea mussels with different ecological niches, finding that habitat homogeneity and mixotrophy reduce geographic structuring of symbiont strains.

Isolation and Transfection of Rice Egg Cells and Zygotes for Cellular Localization

This study isolates and transfects rice egg cells and zygotes to study cell cycle factors during embryogenesis.

In depth exploration of the alternative proteome of Drosophila melanogaster

This study identifies 401 alternative proteins in Drosophila melanogaster through peptidomics, showing some are more abundant than canonical proteins and exhibit developmentally regulated or stress-induced expression.

Proton export drives the Warburg Effect

This study shows that proton export drives the Warburg Effect by increasing intracellular alkalization, enhancing glycolytic flux, and promoting cancer aggressiveness.

A Scribble-E-cadherin complex controls daughter cell patterning by multiple mechanisms

This study identifies how the Scribble-E-cadherin complex regulates daughter cell positioning through multiple mechanisms involving spindle orientation and junction formation.

In vivo lentiviral vector gene therapy to cure hereditary tyrosinemia type 1 and prevent development of precancerous and cancerous lesions

This study cures hereditary tyrosinemia type 1 in pigs using in vivo lentiviral gene therapy, preventing liver fibrosis and tumorigenic pathways.

Developing and Deploying a Scalable Computing Platform to Support MOOC Education in Clinical Data Science

The paper develops a scalable computing platform for MOOCs in clinical data science that securely manages access to sensitive health datasets and supports over 2300 students from 101 countries.

Deep data mining reveals variable abundance and distribution of microbial reproductive manipulators within and among diverse host species

The paper uses data mining to analyze microbial reproductive manipulators in host species, finding Wolbachia infects most arthropods and nematodes, with host species explaining significant variation in bacterial density.

Developing T cells form an immunological synapse for passage through the β-selection checkpoint

The paper shows developing T cells form an immunological synapse to pass the β-selection checkpoint, integrating signals from Notch, CXCR4, and MHC.

Lymph Nodes Inhibit T-cell Effector Functions Locally by Establishing Acidic Niches

The paper shows that acidic niches in lymph nodes inhibit T-cell effector functions by blocking lactic acid efflux and reducing glycolysis, keeping T-cells in a state of stasis.