Prefrontal Cortex Astroglia Modulate Anhedonia-like Behavior
Sierra A. Codeluppi-Arrowsmith, M. Xu, Yashika Bansal, Ashley E. Lepack, V. Duric, M. Chow, Jessie Muir, Rosemary C. Bagot, Pawel Licznerski, Stacey L. Wilber, Gerard Sanacora, Etienne L. Sibille, Ronald S. Duman, Christopher Pittenger, Mounira Banasr
This study shows that depletion of PFC GFAP+ astroglia induces anhedonia-like behavior, while their activation reverses stress-induced anhedonia, highlighting their role in depression.
bioRxiv · May 31, 2023 · PreprintNeuroscience