Author

K. Izawa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Kitaura· 2 shared K. Mukai· 2 shared T. Taguchi· 2 shared A. Gallardo-Orihuela· 1 shared A. Sanz· 1 shared A. Tojo· 1 shared B. Ryffel· 1 shared C. Wang· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

J. Kitaura

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Emergence of putative energy parasites within Clostridia revealed by genome analysis of a novel endosymbiotic clade

K. Takahashi, H. Kuwahara, Y. Horikawa, K. Izawa, D. Kato, T. Inagaki, M. Yuki, M. Ohkuma, Y. Hongoh

The paper identifies three endosymbiotic Clostridia in termite gut protists, revealing they are energy parasites with genome features suggesting obligate intracellular parasitism.

bioRxiv · Jul 3, 2023 · PreprintMicrobiology

NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype

I. Muela-Zarzuela, J. M. Suarez-Rivero, A. Gallardo-Orihuela, C. Wang, K. Izawa, M. de Gregorio-Procopio, I. Couillin, B. Ryffel, J. Kitaura, A. Sanz, T. von Zglinicki, G. Mbalaviele, M. D. Cordero

This study shows that NLRP1 inflammasome promotes senescence and SASP through GSDMD-dependent regulation of p16, p21, p53, and SASP expression.

bioRxiv · Feb 6, 2023 · PreprintImmunology

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

K. Miyake, T. Shibata, R. Sato, M. Taoka, S.-I. Saitoh, M. Komine, K. Yamaguchi, S. Goyama, Y. Motoi, J. Kitaura, K. Izawa, Y. Yamauchi, Y. Tsukamoto, T. Ichinohe, E. Fujita, , T. Taguchi

This study identifies TLR7/8 as drivers of histiocytosis in SLC29A3 disorders by responding to lysosomal nucleoside stress and enhancing monocyte proliferation and phagocyte maturation.

bioRxiv · Oct 27, 2022Immunology

Aberrant localization of CDC42 C-terminal variants to the Golgi apparatus drives pyrin inflammasome-dependent autoinflammation

M. Nishitani-Isa, K. Mukai, Y. Honda, H. Nihira, H. Shibata, T. Tanaka, K. Kodama, E. Hiejima, K. Izawa, Y. Kawasaki, M. Osawa, Y. Katata, S. Onodera, T. Watanabe, S. Kure, , T. Yasumi

This study identifies that CDC42 C-terminal variants cause aberrant Golgi localization, leading to pyrin inflammasome activation and autoinflammation.

bioRxiv · Sep 3, 2021Immunology