Author

M. D. Neinast

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Z. Arany· 2 shared C. E. Bowman· 1 shared C. Jang· 1 shared C. Jiang· 1 shared D. Bartee· 1 shared D. Brady· 1 shared E. L. Varner· 1 shared E. Rame· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPharmacology & Toxicology

Z. Arany

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2 papers

Recent·Most cited

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK

C. E. Bowman, M. D. Neinast, C. Jang, J. Patel, M. C. Blair, E. T. Mirek, W. O. Jonsson, Q. Chu, L. Merlo, L. Mandik-Nayak, T. G. Anthony, J. D. Rabinowitz, Z. Arany

This study shows that BT2, an inhibitor of BCKDK, reduces plasma tryptophan by displacing it from albumin, revealing an off-target effect on tryptophan metabolism.

bioRxiv · Mar 5, 2024Pharmacology & Toxicology

Direct anabolic three carbon metabolism via propionate to a six carbon metabolite occurs in human heart and in vivo across mouse tissues

M. T. Doan, M. D. Neinast, E. L. Varner, K. Bedi, D. Bartee, H. Jiang, S. Trefely, P. Xu, J. P. Singh, C. Jiang, E. Rame, D. Brady, J. L. Meier, K. Marguiles, Z. Arany, N. W. Snyder

The paper confirms the in vivo synthesis of a six-carbon metabolite from propionate in human heart and mouse tissues through non-oxidative pathways.

bioRxiv · Jun 15, 2020 · PreprintBiochemistry