Author

K. Bedi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

K. B. Margulies· 2 shared M. Ljungman· 2 shared A. A. Palmer· 1 shared A. Barkley-Levenson· 1 shared A. Guilbaud· 1 shared A. K. Salomon· 1 shared A. Kreymerman· 1 shared A. M. Chinnaiyan· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

K. B. Margulies

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Tissue- and sex-specific DNA damage tracks aging in rodents and humans

A. Guilbaud, F. Ghanegolmohammadi, Y. Wang, J. Leng, A. Kreymerman, J. Gamboa Varela, J. Garbern, H. Elwell, F. Cao, E. M. Ricci-Blair, C. Liang, S. Balamkundu, C. Vidoudez, M. S. DeMott, K. Bedi, , P. C. Dedon

This study identifies DNA damage patterns across tissues and sexes in rodents and humans, revealing age- and sex-dependent variations in DNA adducts and their potential as disease markers.

bioRxiv · Nov 28, 2022 · PreprintBiochemistry

Multivalent proteins rapidly and reversibly phase-separate upon osmotic cell volume change

A. P. Jalihal, S. Pitchiaya, L. Xiao, P. Bawa, X. Jiang, K. Bedi, A. Parolia, M. Cieslik, M. Ljungman, A. M. Chinnaiyan, N. G. Walter

The paper shows multivalent proteins rapidly phase-separate during hyperosmotic stress and reversibly dissolve upon osmotic rescue, impacting transcription termination.

Molecular Cell · Sep 1, 2020Peer-reviewedCell Biology

Direct anabolic three carbon metabolism via propionate to a six carbon metabolite occurs in human heart and in vivo across mouse tissues

M. T. Doan, M. D. Neinast, E. L. Varner, K. Bedi, D. Bartee, H. Jiang, S. Trefely, P. Xu, J. P. Singh, C. Jiang, E. Rame, D. Brady, J. L. Meier, K. Marguiles, Z. Arany, N. W. Snyder

The paper confirms the in vivo synthesis of a six-carbon metabolite from propionate in human heart and mouse tissues through non-oxidative pathways.

bioRxiv · Jun 15, 2020 · PreprintBiochemistry

KMT2D Links TGF-β Signalling to Non-Canonical Activin Pathway and Regulates Pancreatic Cancer Cell Plasticity

S. Lu, H. S. Kim, Y. Cao, K. Bedi, K. Chain, L. Zhao, I. V. Narayanan, Z. Yi, J. Yang, Y. Gu, M. T. Paulsen, M. Ljungman, S. Jeyarajan, D. Thomas, Y. Dou, , J. Shi

This study identifies KMT2D as a tumor suppressor in pancreatic cancer, linking TGF-β signaling to the non-canonical activin A pathway through miR-147b and showing its role in cancer cell plasticity and metastasis.

bioRxiv · Apr 2, 2020Cancer Biology

Microtubules provide a viscoelastic resistance to myocyte motion.

M. A. Caporizzo, C. Y. Chen, A. K. Salomon, K. Bedi, K. B. Margulies, B. Prosser

This study investigates the mechanical role of microtubules in myocytes, finding they provide viscoelastic resistance that affects contraction and relaxation.

bioRxiv · Jul 3, 2018Biophysics