M. DuPage

Increased EZH2 function in regulatory T cells promotes their capacity to suppress autoimmunity by driving effector differentiation prior to activation

This study shows that increased EZH2 activity in regulatory T cells enhances their effector differentiation and autoimmunity suppression capacity.

Cellular mechanisms underlying beneficial versus detrimental effects of bacterial antitumor immunotherapy

This study investigates how different routes of Listeria monocytogenes administration affect tumor growth in mice, finding that IV followed by IT administration controls tumor growth through anti-Lm CD8 T cells.

A mass cytometry approach to track the evolution of T cell responses during infection and immunotherapy by paired T cell receptor repertoire and T cell differentiation state analysis

The paper develops a mass cytometry method to track T cell receptor repertoires and differentiation states during infection and immunotherapy, showing how antigen recognition influences T cell responses.