D. A. Portnoy

Cellular mechanisms underlying beneficial versus detrimental effects of bacterial antitumor immunotherapy

This study investigates how different routes of Listeria monocytogenes administration affect tumor growth in mice, finding that IV followed by IT administration controls tumor growth through anti-Lm CD8 T cells.

Listeria monocytogenes utilizes glutathione and limited inorganic sulfur compounds as a source of essential L-cysteine

This study identifies GSH and inorganic sulfur compounds as sources of L-cysteine for Listeria monocytogenes growth and virulence.

Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens

Distinct energy-coupling factor transporter subunits enable flavin acquisition and extracytosolic trafficking for extracellular electron transfer in Listeria monocytogenes

This study identifies ECF transporter subunits involved in flavin export for flavinylation in L. monocytogenes and shows their directional transport and genomic distribution.

Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis

This study shows that Listeria monocytogenes uses cellular respiration for NAD+ regeneration, which is critical for its pathogenesis and survival in host cells.

Comparative analysis of macrophage post-translational modifications during intracellular bacterial pathogen infection

This study uses proteomics to analyze post-translational modifications in macrophages infected with three intracellular pathogens, revealing pathogen-specific molecular responses and a novel mechanism of virus-bacterial synergy.

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

This study identifies SP140 as a repressor of type I interferons that enhances resistance to bacterial infections like Legionella pneumophila and Mycobacterium tuberculosis.