M. F. Beers

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells

This study compares how SARS-CoV-2 and other betacoronaviruses activate the IRE1α/XBP1 ER stress pathway in human lung cells, finding that SARS-CoV-2 only partially activates it, potentially evading host immune detection.

Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease

This study uses patient-derived iPSCs with an SFTPC mutation to model early alveolar epithelial dysfunction in interstitial lung disease, revealing proteostasis, metabolic, and inflammatory changes.