Author

D. Parekh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:cryo-EM· 2 Organism:virus· 2 Research Focus:cell type annotation· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

E. O. Saphire· 3 shared K. Shaffer· 3 shared S. Hui· 3 shared V. Rayaprolu· 3 shared A. Parvate· 2 shared C. Hariharan· 2 shared H. Callaway· 2 shared S. L. Schendel· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

E. O. Saphire

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A broadly-neutralizing antibody against Ebolavirus glycoprotein that potentiates the breadth and neutralization potency of other antibodies

F. R. Donnellan, V. Rayaprolu, P. Rijal, V. O'Dowd, A. Parvate, H. Callaway, C. Hariharan, D. Parekh, S. Hui, K. Shaffer, R. Diaz Avalos, K. Hastie, L. Schimanski, H. Müller-Kräuter, T. Strecker, , S. J. Draper

The paper identifies two broadly neutralizing antibodies against Ebolavirus glycoprotein and shows that one enhances the neutralization breadth and potency of other antibodies.

bioRxiv · Jun 21, 2024Immunology

Intracellular Ebola Virus nucleocapsid assembly revealed by in situ cryo-electron tomography.

R. Watanabe, D. Zyla, D. Parekh, C. Hong, Y. Jones, S. L. Schendel, W. Wan, G. Castillon, E. O. Saphire

This study uses cryo-electron tomography to reveal the structure of the intracellular Ebola virus nucleocapsid, identifying a new outer layer of NP complexed with VP35 and conserved assembly interfaces.

bioRxiv · Dec 1, 2023Microbiology

Structure of the Inmazeb cocktail and resistance to escape against Ebola virus

V. Rayaprolu, B. Fulton, A. Rafique, E. Arturo, D. Williams, C. Hariharan, H. Callaway, A. Parvate, S. L. Schendel, D. Parekh, S. Hui, K. Shaffer, K. E. Pascal, E. Wloga, S. Giordano, , E. O. Saphire

The paper presents the cryoEM structure of the Inmazeb cocktail in complex with Ebola virus glycoprotein, showing how the combination prevents escape mutations better than monotherapy.

bioRxiv · Oct 11, 2022Biophysics

Glycan shield of the ebolavirus envelope glycoprotein GP

W. Peng, V. Rayaprolu, A. D. Parvate, M. F. Pronker, S. Hui, D. Parekh, K. Shaffer, X. Yu, E. O. Saphire, J. Snijder

This study profiles the site-specific glycosylation patterns of ebolavirus GP using mass spectrometry, revealing complex N-, O-, and C-linked glycans that contribute to the glycan shield and restrict antibody neutralization.

bioRxiv · Feb 7, 2022Biochemistry