Author

M. G. Plach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

T. Schubert· 2 shared A. Grigorescu· 1 shared A. Hamai· 1 shared A. Rahi· 1 shared C. Ansaldi· 1 shared C. Battle· 1 shared C. Drouot· 1 shared C. Kleusch· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

T. Schubert

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SAXS/MC studies of the mixed-folded protein Cdt1 reveal monomeric, folded over conformations

K. P. Smith, S. Chakravarthy, A. Rahi, M. Chakraborty, K. M. Vosberg, M. Tonelli, M. G. Plach, A. Grigorescu, J. E. Curtis, D. Varma

This study uses biophysical and computational methods to characterize the structure of human Cdt1, revealing 'folded over' conformations that suggest a scaffold function.

bioRxiv · Jan 3, 2024 · PreprintBiophysics

Impact of single mutations on binding kinetics oftriplex forming oligos revealed by fluorescence proximitysensing in heliX(R) biosensor

V. Molkenthin, D. Baumstark, T. Schubert, G. Längst, M. G. Plach

The paper uses the heliX biosensor to measure binding kinetics of triplex forming oligos, revealing how single mutations affect dissociation constants and binding rates.

bioRxiv · Nov 21, 2022 · PreprintBiophysics

Multi-parameter formulation development for an HIV-vaccine protein with direct validation of epitope binding integrity and stoichiometry

C. Popp, P. Schramm, R. Wagner, D. Peterhoff, C. Battle, C. Kleusch, M. G. Plach

The paper develops a multi-parameter formulation for an HIV vaccine protein, validating epitope binding and stoichiometry using advanced biophysical tools.

bioRxiv · Nov 30, 2020 · PreprintBiophysics

GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions

S. BRUN, E. Raymond, F. Bassissi, Z. M. Jilkova, S. Mezouar, M. Rachid, M. Novello, J. Tracz, A. Hamai, G. Lalmanach, L. Vanderlynden, E. Bestion, R. Legouffe, J. Stauber, T. Schubert, , P. Halfon

This paper evaluates GNS561, a PPT1 inhibitor, showing its efficacy against HCC by modulating lysosomal functions and inducing cell death in vitro and in vivo.

bioRxiv · Sep 30, 2020Cancer Biology