M. Tonelli

SAXS/MC studies of the mixed-folded protein Cdt1 reveal monomeric, folded over conformations

This study uses biophysical and computational methods to characterize the structure of human Cdt1, revealing 'folded over' conformations that suggest a scaffold function.

MEMO1 is a Metal Containing Regulator of Iron Homeostasis in Cancer Cells

This study identifies MEMO1 as an iron-binding protein that regulates iron homeostasis in cancer cells through interactions with iron-related proteins and its role in ferroptosis.

Structural insights into acetylated histone ligand recognition by the BDP1 bromodomain of Plasmodium falciparum

This study investigates the binding specificity of PfBDP1 bromodomain to acetylated histones in P. falciparum, revealing its preference for tetra-acetylated H4 and potential therapeutic implications.

Reassessing the helix bundle crossing model for gating in a non-selective ion channel

The paper uses NMR to show that NaK channels are in an open conformation despite being non-conductive, challenging the helix bundle crossing gating model.

The mechanism of RNA capping by SARS-CoV-2

This study reveals how SARS-CoV-2 caps its RNA genome through an unconventional mechanism involving RNAylation and methyltransferase activity, identifying potential antiviral targets.

A Cryptic K48 Ubiquitin Chain Binding Site on UCH37 is Required for its Role in Proteasomal Degradation

pH-dependent polymorphism of the structure of SARS-CoV-2 nsp7

This study determines the solution structure of SARS-CoV-2 nsp7 at pH 7.0 using NMR spectroscopy and identifies pH-dependent structural changes in the protein.

Coordination of di-acetylated histone ligands by the ATAD2 bromodomain

This study identifies how the ATAD2 bromodomain recognizes di-acetylated histone tails through residue-specific interactions and confirms its monomeric state using biophysical techniques.

Ion-dependent structure, dynamics, and allosteric coupling in a non-selective cation channel

This study investigates how bound Na+ and K+ ions affect the structure and dynamics of the NaK channel's selectivity filter, revealing dynamic behavior and allosteric coupling.

Urea nitrogen recycling via gut symbionts increases in hibernators over the winter fast

This study shows that hibernating ground squirrels recycle urea nitrogen through their gut microbiome to maintain protein balance during winter fasting.

Structural insights into the recognition of mono- and di-acetylated histones by the ATAD2B bromodomain

This study investigates the ligand specificity of the ATAD2B bromodomain, showing it binds mono- and di-acetylated histones and identifies structural features critical for this recognition.