Author

M. Ganguly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Assay:cryo-EM· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Approach:deep learning· 1

Frequent Co-Authors

A. K. SHUKLA· 4 shared R. Banerjee· 4 shared S. Saha· 4 shared J. Maharana· 3 shared M. Yadav· 3 shared P. Sarma· 3 shared S. Mishra· 3 shared V. Singh· 3 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersBiochemistry

A. K. SHUKLA

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Author profile →

4 papers

Recent·Most cited

Molecular basis of ligand promiscuity, structural mimicry, and atypical dimerization in the chemokine receptors

S. Saha, F. K. Sano, S. Sharma, M. Ganguly, S. Saha, H. Akasaka, T. A. Kobayashi, N. Zaidi, S. Mishra, A. Dalal, S. Mohapatra, M. Yadav, Y. Itoh, R. Leurs, A. Chevigne, , A. K. SHUKLA

This study investigates ligand promiscuity and signaling bias in chemokine receptors by analyzing binding modes and determining cryo-EM structures of receptor-ligand complexes.

bioRxiv · Feb 1, 2024 · PreprintBiochemistry

Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution

M. Yadav, P. Sarma, M. Ganguly, S. Mishra, J. Maharana, N. Zaidi, A. Dalal, V. Singh, S. Saha, G. Mahajan, S. Sharma, M. Chami, R. Banerjee, A. K. Shukla

This study presents cryo-EM structures of GPR109A-G-protein complexes with agonists and uses them to engineer biased agonists with reduced flushing effects.

bioRxiv · Jul 3, 2023 · PreprintBiochemistry

Structural insights into agonist-binding and activation of the human complement C3a receptor

M. K. Yadav, R. Yadav, P. Sarma, J. Maharana, C. Soni, S. Saha, V. Singh, M. Ganguly, S. Saha, H. Khant, R. Banerjee, A. K. Shukla, C. Gati

This study presents structural insights into C3a-C3aR interactions and identifies a G-protein-biased agonist for the receptor.

bioRxiv · Feb 9, 2023 · PreprintBiochemistry

Structural insights into ligand-recognition, activation, and signaling-bias at the complement C5a receptor, C5aR1

A. K. Shukla, S. Saha, J. Maharana, M. Yadav, P. Sarma, V. Singh, S. Mohapatra, C. Soni, S. Saha, S. Mishra, M. Ganguly, M. Chami, R. Banerjee

This study presents cryo-EM structures of C5aR1 bound to C5a and a synthetic peptide, revealing conformational changes and G-protein coupling mechanisms.

bioRxiv · Jan 14, 2023 · PreprintBiophysics