M. K. Yadav

Molecular insights into atypical modes of beta-arrestin interaction with seven transmembrane receptors

This study presents cryo-EM structures and experimental data revealing how beta-arrestins interact with GPCRs, particularly those with phosphorylation in the third intracellular loop and intrinsically biased receptors.

RBM3 enhances cold resistance by regulating thermogenic gene expressions

This study shows RBM3 enhances cold resistance by regulating thermogenic gene expression in brown adipose tissue and activating hypothalamic neurons in juvenile mice.

Structural insights into agonist-binding and activation of the human complement C3a receptor

This study presents structural insights into C3a-C3aR interactions and identifies a G-protein-biased agonist for the receptor.

Structural snapshots uncover a lock-and-key type conserved activation mechanism of β-arrestins by GPCRs

The paper presents structural snapshots of β-arrestins interacting with GPCRs, revealing a conserved 'lock-and-key' activation mechanism through specific phosphorylation patterns.

Human endogenous retrovirus-R envelope is a host restriction factor against severe acute respiratory syndrome-coronavirus-2

The paper identifies HERV-R envelope as a host restriction factor that inhibits SARS-CoV-2 replication through ERK and p38 MAPK signaling.

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

This study characterizes the biased agonism of CXCR4 and CXCR7, revealing differences in G-protein coupling, β-arrestin recruitment, and ERK1/2 activation.

Docosahexaenoic acid (DHA), a nutritional supplement, modulates steroid insensitivity in asthma

This study shows DHA improves steroid sensitivity in asthma models and is lower in steroid-insensitive asthmatics.