Author

M. Garnett

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

E. Goncalves· 2 shared J. Saez-Rodriguez· 2 shared A. Barthorpe· 1 shared A. Beck· 1 shared A. Butler· 1 shared A. Matchan· 1 shared A. Peryt· 1 shared A. S. Coonar· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

E. Goncalves

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Author profile →

4 papers

Recent·Most cited

Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma

J. Obacz, R. Nibhani, T. S. Adams, J. C. Schupp, J. A. Valer, N. Veale, G. Aresu, A. S. Coonar, A. Peryt, G. Biffi, N. Kaminski, H. E. Francies, D. Rassl, M. Garnett, R. C. Rintoul, S. J. Marciniak

This study presents a single-cell transcriptomic atlas of human pleura, identifying stromal heterogeneity and informing in vitro models of mesothelioma.

bioRxiv · Dec 3, 2022 · PreprintCancer Biology

A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens

S. Price, S. G. Bhosle, E. Goncalves, X. Li, D. McClurg, A. Barthorpe, A. Beck, C. Hall, H. Lightfoot, L. Farrow, R. Ansari, D. A. Jackson, L. Allen, K. Roberts, C. Beaver, , M. Garnett

This paper introduces a suspension culture technique for cancer organoids that improves expansion efficiency and enables large-scale perturbation screens.

bioRxiv · Oct 23, 2021Cancer Biology

A statistical framework for assessing pharmacological response and biomarkers using uncertainty estimates

D. Wang, J. Hensman, G. Kutkaite, T. S. Toh, GDSC Screening Team, J. R. Dry, J. Saez-Rodriguez, M. Garnett, M. P. Menden, F. Dondelinger

The paper introduces a statistical framework using uncertainty estimates to identify biomarkers from drug screening data, finding 24 known and 6 novel biomarkers in cancer cell lines.

bioRxiv · May 1, 2020 · PreprintCancer Biology

Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR/Cas9 screening

M. Garnett, G. Picco, E. Chen, L. Garcia Alonso, F. Behan, E. Goncalves, G. Bignell, A. Matchan, B. Fu, R. Banerjee, E. Anderson, A. Butler, C. Benes, U. McDermott, D. Dow, , J. Saez-Rodriguez

The paper functionally links gene fusions to cancer cell fitness using drug sensitivity and CRISPR-Cas9 data, identifying rare functional fusions and novel therapeutic targets.

bioRxiv · Feb 24, 2019Cancer Biology