M. P. Menden

MetaIBS: large-scale amplicon-based meta analysis of irritable bowel syndrome

MetaIBS performs a large-scale meta-analysis of 16S rRNA amplicon data from IBS patients and healthy controls, identifying consistent microbial taxa differences.

The pharmacogenomic assessment of molecular epithelial-mesenchymal transition signatures reveals drug susceptibilities in cancer cell lines

The paper assesses molecular EMT signatures in cancer cell lines to identify drug susceptibilities, showing EMT can predict responses to HSP90 inhibitors and enhance drug sensitivity through TGF-β stimulation.

The pharmacoepigenomic landscape of cancer cell lines reveals the epigenetic component of drug sensitivity

The paper identifies DNA methylation biomarkers linked to drug sensitivity in cancer cell lines across multiple cancer types and drugs.

The myocyte Nfe2l1-ubiquitin-proteasome system controls muscle fiber type and obesity-induced insulin resistance

This study shows that Nfe2l1 regulates skeletal muscle proteostasis and function, with its loss causing muscle fiber type switching and insulin resistance in high-fat diet conditions.

Suppression of ferroptosis by vitamin A or antioxidants is essential for neuronal development

This study shows that suppressing ferroptosis via antioxidants or vitamin A is necessary for proper neuronal development and laminar organization in cortical organoids.

Low numbers of cytokine transcripts drive inflammatory skin diseases by initiating amplification cascades in localized epidermal clusters

A statistical framework for assessing pharmacological response and biomarkers using uncertainty estimates

The paper introduces a statistical framework using uncertainty estimates to identify biomarkers from drug screening data, finding 24 known and 6 novel biomarkers in cancer cell lines.

GDSCTools for Mining Pharmacogenomic Interactions in Cancer

GDSCTools provides a software package for analyzing pharmacogenomic data to identify genomic markers of drug response in cancer.