L. Koepke

SARS-CoV-2 Omicron Envelope T9I adaptation confers resistance to autophagy

The paper shows that the T9I mutation in the SARS-CoV-2 E protein confers autophagy resistance in Omicron variants, contributing to their spread.

SARS-CoV-2 variants of concern are dependent on IFITM2 for efficient replication in human lung cells

The paper was withdrawn due to duplicate submission and is not intended for citation.

SARS-CoV-2 variants of concern remain dependent on IFITM2 for efficient replication in human lung cells

This study shows that SARS-CoV-2 variants of concern (VOCs) require IFITM2 for efficient replication in human lung cells, with IFITM2 depletion reducing viral RNA and infectious virus production by over four orders of magnitude.

The Delta variant of SARS-CoV-2 maintains high sensitivity to interferons in human lung cells

This study examines IFN sensitivity of SARS-CoV-2 variants, finding Delta remains as sensitive as early isolates, while Alpha, Beta, and Gamma show increased resistance.

Spike mutation T403R allows bat coronavirus RaTG13 to use human ACE2

The paper shows that a single amino acid mutation in the Spike protein of bat coronavirus RaTG13 enables it to use human ACE2 for infection.

Imperfect innate immune antagonism renders SARS-CoV-2 vulnerable towards IFN-γ and -{lambda}

This study identifies SARS-CoV-2's vulnerability to IFN-γ and -λ due to its inefficient antagonism of type I and II IFN responses, suggesting potential therapeutic strategies.

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition

This study shows that IFITM proteins are required for SARS-CoV-2 infection and can be targeted to inhibit viral entry and replication.

Remdesivir but not famotidine inhibits SARS-CoV-2 replication in human pluripotent stem cell-derived intestinal organoids

This study uses human intestinal organoids to show that remdesivir inhibits SARS-CoV-2 replication, while famotidine does not.