M. Irimia

An amphioxus neurula stage cell atlas supports a complex scenario for the emergence of vertebrate head mesoderm

The paper constructs a single-cell RNA-seq atlas of amphioxus neurula stage to investigate the evolutionary origins of vertebrate head mesoderm.

Parallel evolution of amphioxus and vertebrate small-scale gene duplications

This study compares small-scale gene duplication patterns between amphioxus and vertebrates, finding similar duplication histories and functional constraints despite amphioxus' slower evolution.

Evolutionary conservation of A/T-ending codons reflects co-regulation of expression and complex formation.

The paper shows that A/T-ending codons are conserved and co-regulated, enabling coordinated protein expression and complex formation across vertebrates.

The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians

This study identifies Mbnl3 as a placenta-specific X-linked gene that restricts placental growth in eutherians through altered RNA binding specificities and novel biological functions.

Hypersilencing of SRRM4 suppresses basal microexon inclusion and promotes tumor growth across cancers

This study shows that SRRM4 silencing in tumors suppresses microexon inclusion and promotes tumor growth by shifting cells toward differentiation.

Alternative splicing landscapes in Arabidopsis thaliana across tissues and stress conditions highlight major functional differences with animals

The paper analyzes alternative splicing in Arabidopsis thaliana across tissues and stress conditions, revealing distinct regulatory patterns compared to animals.

Genomic adaptations to aquatic and aerial life in mayflies and the origin of wings in insects

This study analyzes the genome and gene expression of mayflies to uncover genomic adaptations related to aquatic and aerial life and the origin of wings in insects.

Ancient genomic regulatory blocks are a major source for gene deserts in vertebrates after whole genome duplications

The paper shows that ancient genomic regulatory blocks (GRBs) were maintained as single copies in humans after vertebrate whole genome duplications, with their duplicated copies dismantled to form gene deserts.