ERK signaling licenses SKN-1A/NRF1 for proteasome production and proteasomal stress resistance
P. Zhang, H.-Y. Qu, Z. Wu, H. Na, J. Hourihan, F. Zhang, F. Zhu, M. Isik, A. J. M. Walhout, Y.-X. Feng, K. Blackwell
This study identifies ERK1/2-mediated phosphorylation of NRF1 as critical for proteasome production and stress resistance, showing therapeutic potential in cancer.
bioRxiv · Jan 4, 2021 · PreprintCell Biology