Author

A. J. M. Walhout

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

B. W. Fox· 1 shared F. C. Schroeder· 1 shared F. Zhang· 1 shared F. Zhu· 1 shared G. E. Giese· 1 shared H. Na· 1 shared H. Zhang· 1 shared H.-Y. Qu· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

B. W. Fox

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A D-2-Hydroxyglutarate dehydrogenase mutant reveals a critical role for ketone body metabolism in Caenorhabditis elegans development

O. Ponomarova, H. Zhang, X. Li, S. Nanda, T. B. Leland, B. W. Fox, G. E. Giese, F. C. Schroeder, S. L. Yilmaz, A. J. M. Walhout

This study shows that in C. elegans, D-2HG is produced via the propionate shunt and that loss of dhgd-1 causes embryonic lethality by disrupting ketone body metabolism, which can be rescued by vitamin B12 or 3-hydroxybutyrate.

bioRxiv · May 16, 2022Biochemistry

ERK signaling licenses SKN-1A/NRF1 for proteasome production and proteasomal stress resistance

P. Zhang, H.-Y. Qu, Z. Wu, H. Na, J. Hourihan, F. Zhang, F. Zhu, M. Isik, A. J. M. Walhout, Y.-X. Feng, K. Blackwell

This study identifies ERK1/2-mediated phosphorylation of NRF1 as critical for proteasome production and stress resistance, showing therapeutic potential in cancer.

bioRxiv · Jan 4, 2021 · PreprintCell Biology