G. W. Yeo

Functional Diversity of Memory CD8 T Cells is Spatiotemporally Imprinted

The paper investigates how spatial location influences the functional diversity of memory CD8 T cells by analyzing their transcriptomes in the small intestine.

A phage nucleus-associated RNA-binding protein is required for jumbo phage infection

This study identifies ChmC, a phage protein that binds RNA and facilitates mRNA transport through the phage nucleus-like compartment, essential for infection.

Stratification of enterochromaffin cells by single-cell expression analysis

This study identifies fourteen enterochromaffin cell clusters in the gut using single-cell transcriptomics and spatial analysis, revealing subtypes with distinct functional properties and a Piezo2+ population involved in colon motility.

Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration.

This study identifies Zfp697 as a regulator of muscle regeneration and inflammation by mediating interferon gamma signaling and interacting with ncRNAs like miR-206.

LARP4 Is an RNA-Binding Protein That Binds Nuclear-Encoded Mitochondrial mRNAs To Promote Mitochondrial Function

VPS13A and VPS13C influence lipid droplet abundance

This study shows that loss of VPS13A or VPS13C reduces lipid droplet abundance in cells under oleate-stimulated conditions.

A two-step in vivo CRISPR screen unveils pervasive RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a therapeutic target

This study identifies RNA binding proteins essential for leukemic stem cell survival using an in vivo CRISPR screen and highlights ELAVL1 as a therapeutic target in AML.

Junior scientists spotlight social bonds in seminars for diversity, equity, and inclusion in STEM

The paper analyzes seminar talks by junior scientists to assess how they discuss diversity, equity, and inclusion in STEM, finding common themes and intersectional identities.

Identification of the Global miR-130a Targetome Reveals a Novel Role for TBL1XR1 in Hematopoietic Stem Cell Self-Renewal and t(8;21) AML

This study identifies miR-130a as a regulator of HSC self-renewal and differentiation, with TBL1XR1 as a key target, and shows its role in maintaining the oncogenic program in t(8;21) AML.

Comparison of heat-inactivated and infectious SARS-CoV-2 across indoor surface materials shows comparable RT-qPCR viral signal intensity and persistence

This study compares RT-qPCR signal intensity and persistence of heat-inactivated and infectious SARS-CoV-2 on different surfaces, showing similar decay patterns and enabling simplified environmental monitoring protocols.

Splicing Factor SRSF1 Deficiency in the Liver Triggers NASH-like Pathology via R-Loop Induced DNA Damage and Cell Death

Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies

This study investigates how RBM20 mutations affect splicing and ribonucleoprotein granules in cardiomyopathy, revealing distinct pathogenic mechanisms between missense and knockout mutations.

ADAR2 deaminase activity promotes Th17 effector function and protects against intestine inflammation

This study shows ADAR2 promotes Th17 effector function by editing Malt1, leading to increased IL-17A and protection against intestinal inflammation.

DDX5 targets tissue-specific RNAs to promote intestine tumorigenesis

This study identifies DDX5 as a regulator of tissue-specific oncogenic RNAs in intestinal tumorigenesis, showing its role in promoting colon and small intestine cancers.

Functional delineation of tissue-resident CD8 T cell heterogeneity during infection and cancer

This study identifies distinct CD8+ T cell subsets in non-lymphoid tissues during infection and cancer, revealing their functional roles and regulatory mechanisms.

Cancer avatars derived from genetically engineered pluripotent stem cells allow for longitudinal assessment of tumor development

This paper introduces cancer avatar models using genetically engineered hiPSCs to study tumor development and heterogeneity in glioblastoma.

Sequence, Structure and Context Preferences of Human RNA Binding Proteins

The paper presents affinity landscapes of 78 human RNA binding proteins using deep sequencing to determine sequence, structure, and context preferences, revealing patterns of low motif diversity and contextual feature preferences.