Author

M. S. Cuoco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Cell Biology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell type annotation· 5 Approach:statistical model· 5 Research Focus:differential expression· 4 Assay:scRNA-seq· 4 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Approach:deep learning· 2

Frequent Co-Authors

A. Regev· 6 shared O. Rozenblatt-Rosen· 5 shared O. Cohen· 3 shared D. Dionne· 2 shared D. R. Zollinger· 2 shared J. E. Buendia-Buendia· 2 shared J. Waldman· 2 shared N. Wagle· 2 shared

Activity by Year

2019-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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6 shared papersCancer Biology

A. Regev

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Author profile →

8 papers

Recent·Most cited

Junior scientists spotlight social bonds in seminars for diversity, equity, and inclusion in STEM

E. A. Boyle, G. Goldberg, J. C. Schmok, J. Burgado, F. Izidro Layng, H. A. Grunwald, K. M. Balotin, M. S. Cuoco, K.-C. Chang, G. Ecklu-Mensah, A. K. S. Arakaki, N. Ahmed, X. Garcia Arceo, P. Jagannatha, J. Pekar, , G. W. Yeo

The paper analyzes seminar talks by junior scientists to assess how they discuss diversity, equity, and inclusion in STEM, finding common themes and intersectional identities.

bioRxiv · Dec 5, 2021Scientific Communication & Education

Single-nucleus cross-tissue molecular reference maps to decipher disease gene function

G. Eraslan, E. Drokhlyansky, S. Anand, A. Subramanian, E. Fiskin, M. Slyper, J. Wang, N. Van Wittenberghe, J. M. Rouhana, J. Waldman, O. Ashenberg, D. Dionne, T. S. Win, M. S. Cuoco, O. Kuksenko, , A. Regev

The paper develops a cross-tissue single-nucleus RNA-seq atlas to identify cell types and gene functions in health and disease.

bioRxiv · Jul 19, 2021Cell Biology

Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer

K. Pelka, M. Hofree, J. Chen, S. Sarkizova, J. D. Pirl, V. Jorgji, A. Bejnood, D. Dionne, W. H. Ge, K. H. Xu, S. X. Chao, D. R. Zollinger, D. J. Lieb, J. W. Reeves, C. A. Fuhrman, , J

The paper identifies immune hubs in colorectal cancer by analyzing transcriptional and spatial patterns in MMRd and MMRp tumors.

bioRxiv · Jan 30, 2021 · PreprintCancer Biology

Cycling cancer persister cells arise from lineages with distinct transcriptional and metabolic programs

Y. Oren, M. Tsabar, H. F. Cabanos, M. S. Cuoco, E. Zaganjor, P. I. Thakore, M. Tabaka, C. P. Fulco, S. A. Hurvitz, D. J. Slamon, G. Lahav, A. Hata, J. S. Brugge, A. Regev

The paper identifies cycling cancer persisters with distinct transcriptional and metabolic programs using a new tracing system and shows that targeting oxidative stress or metabolic reprogramming reduces their fraction.

bioRxiv · Jun 5, 2020Cancer Biology

Pan-cancer single cell RNA-seq uncovers recurring programs of cellular heterogeneity

G. S. Kinker, A. C. Greenwald, R. Tal, Z. Orlova, M. S. Cuoco, J. M. McFarland, A. Warren, C. Rodman, J. A. Roth, S. A. Bender, B. Kumar, J. W. Rocco, P. A. Fernandes, C. C. Mader, H. Keren-Shaul, , I. Tirosh

The paper uses single-cell RNA-seq to analyze cancer cell lines and identifies recurring expression programs of heterogeneity that mirror those in tumors, suggesting intrinsic plasticity contributes to intra-tumoral diversity.

bioRxiv · Oct 21, 2019 · PreprintCancer Biology

Acquired FGFR and FGF alterations confer resistance to estrogen receptor (ER) targeted therapy in ER+ metastatic breast cancer

P. Mao, O. Cohen, K. J. Kowalski, J. G. Kusiel, J. E. Buendia-Buendia, M. S. Cuoco, P. Exman, S. A. Wander, A. G. Waks, U. Nayar, J. Chung, S. Freeman, O. Rozenblatt-Rosen, V. A. Miller, F. Federica Piccioni, , N. Wagle

This study identifies FGFR and FGF pathway alterations as acquired resistance mechanisms to ER-targeted therapy in ER+ metastatic breast cancer and suggests targeted inhibitors as potential treatments.

bioRxiv · Oct 7, 2019Cancer Biology

Opposing immune and genetic forces shape oncogenic programs in synovial sarcoma

L. Jerby, C. Neftel, M. E. Shore, M. J. McBride, B. Haas, B. Izar, H. R. Weissman, A. Volorio, G. Boulay, L. Cironi, A. R. Richman, L. C. Broye, J. M. Gurski, C. C. Luo, R. Mylvaganam, , A. Regev

The paper profiles synovial sarcoma tumors to show that the SS18-SSX fusion drives oncogenic programs, which are repressed by immune cells and can be targeted with HDAC and CDK4/6 inhibitors.

bioRxiv · Aug 4, 2019 · PreprintCancer Biology

Longitudinal single cell profiling of regulatory T cells identifies IL-33 as a driver of tumor immunosuppression

A. Li, R. H. Herbst, D. Canner, J. M. Schenkel, O. C. Smith, J. Y. Kim, M. Hillman, A. Bhutkar, M. S. Cuoco, C. G. Rappazzo, P. Rogers, C. Q. Dang, O. Rozenblatt-Rosen, L. Cong, M. Birnbaum, , T. Jacks

The paper identifies IL-33 as a driver of tumor immunosuppression by analyzing longitudinal single-cell RNA-Seq data of regulatory T cells in a mouse model of lung adenocarcinoma.

bioRxiv · Jan 6, 2019 · PreprintCancer Biology