Author

M. J. Coffey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. G. Longstaff· 2 shared F. Zhao· 2 shared J. J. Gabriel· 2 shared A. D. Uboldi· 1 shared A. I. Webb· 1 shared A. M. Lehane· 1 shared C. J. Tonkin· 1 shared C. Y. Botte· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersPharmacology & Toxicology

D. G. Longstaff

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3 papers

Recent·Most cited

Evaluating the solubility of compounds intended for intramammary infusion based upon tests conducted across a range of milk products using cephapirin sodium and benzathine as model drugs

M. Martinez, F. Zhao, D. G. Longstaff, J. J. Gabriel, M. J. Coffey

This paper evaluates drug solubility in milk products using cephapirin sodium and benzathine as model drugs, finding that whole milk or reconstituted milk can substitute for raw bovine milk for solubility assessments at 38°C.

bioRxiv · Jan 24, 2023Pharmacology & Toxicology

An exploratory study of a simple approach for evaluating drug solubility in milk related vehicles

S. Li, J. J. Gabriel, M. N. Martinez, D. G. Longstaff, M. J. Coffey, F. Zhao

This study evaluates a method for assessing drug solubility in various milk-related vehicles and finds that milk significantly enhances solubility of poorly water-soluble drugs, though the effect varies by drug.

bioRxiv · Oct 27, 2022 · PreprintBiochemistry

Protein Kinase A Negatively Regulates Ca2+ signalling in Toxoplasma gondii

A. D. Uboldi, M.-L. Wilde, E. A. McRae, R. J. Stewart, L. F. Dagley, L. Yang, N. J. Katris, S. V. Hapuarachchi, M. J. Coffey, A. M. Lehane, C. Y. Botte, R. F. Waller, A. I. Webb, C. J. Tonkin

This study shows that Protein Kinase A (PKAc1) suppresses Ca2+ signalling in Toxoplasma gondii after host cell invasion, affecting motility and infectivity.

bioRxiv · Feb 14, 2018Microbiology