Generation and characterisation of P. falciparum parasites with a G358S mutation in the PfATP4 Na+ pump and clinically relevant levels of resistance to some PfATP4 inhibitors
D. Qiu, J. V. Pei, J. E. O. Rosling, D. Li, Y. Xue, J. S. Penington, K. Kümpornsin, Y. T. V. Aw, J. Y. H. Aw, H. Hasemer, A. S. M. Dennis, M. C. Ridgway, A. T. Papenfuss, M. C. S. Lee, G. G. van Dooren, , A. M. Lehane
This paper shows that a G358S mutation in PfATP4 confers clinically relevant resistance to cipargamin and (+)-SJ733 in P. falciparum parasites.
bioRxiv · Jan 11, 2022Microbiology