Author

C. J. Tonkin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Assay:proteomics· 1

Frequent Co-Authors

A. D. Uboldi· 2 shared C. Y. BOTTE· 2 shared M.-L. Wilde· 2 shared N. J. KATRIS· 2 shared A. Garnham· 1 shared A. I. Webb· 1 shared A. M. Lehane· 1 shared A. S. P. YANG· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

A. D. Uboldi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Depletion of voltage-dependent anion channel (VDAC) of Toxoplasma gondii affects multiple mitochondrial functions, but not calcium signalling.

N. Mallo, E. S. dos Santos Martins Duarte, S. C. Baehr, M. Biddau, J. Ovciarikova, M.-L. Wilde, A. D. Uboldi, L. Lemgruber, C. J. Tonkin, J. G. Wideman, C. R. Harding, L. Sheiner

This study shows that VDAC in Toxoplasma gondii is essential for mitochondrial protein import and metabolite transfer but does not regulate calcium signaling.

bioRxiv · Oct 7, 2020 · PreprintCell Biology

Rapid kinetics of lipid second messengers controlled by a cGMP signalling network coordinates apical complex functions in Toxoplasma tachyzoites

N. J. KATRIS, Y. YAMARYO-BOTTE, J. JANOUSKOVEC, S. SHUNMUGAM, C.-S. ARNOLD, A. S. P. YANG, A. VARDAKIS, R. STEWART, R. SAUERWEIN, G. McFADDEN, C. J. TONKIN, M.-F. CESBRON-DELAUW, C. Y. BOTTE

The paper investigates the rapid lipid second messenger dynamics in Toxoplasma tachyzoites, showing how cGMP signaling regulates membrane lipid turnover and coordinates invasion and egress.

bioRxiv · Jun 19, 2020 · PreprintMicrobiology

Toxoplasma gondii bradyzoites induce transcriptional changes to host cells and prevent IFNγ-mediated cell death

C. J. Tonkin, S. Seizova, A. Garnham, M. Coffey, L. Whitehead, K. Rogers

This study shows that Toxoplasma gondii bradyzoites alter host cell transcription and prevent IFNγ-mediated cell death through protein export.

bioRxiv · Jun 13, 2019Microbiology

Identification of a divergent cytochrome c oxidase complex in the mitochondrial proteome of Toxoplasma gondii

A. Seidi, L. S. Muellner-Wong, E. Rajendran, E. T. Tjhin, L. Dagley, V. Y. T. Aw, A. Webb, C. J. Tonkin, G. van Dooren

The paper identifies a divergent cytochrome c oxidase complex in Toxoplasma gondii mitochondria, revealing unique proteins essential for parasite survival.

bioRxiv · May 11, 2018Microbiology

Protein Kinase A Negatively Regulates Ca2+ signalling in Toxoplasma gondii

A. D. Uboldi, M.-L. Wilde, E. A. McRae, R. J. Stewart, L. F. Dagley, L. Yang, N. J. Katris, S. V. Hapuarachchi, M. J. Coffey, A. M. Lehane, C. Y. Botte, R. F. Waller, A. I. Webb, C. J. Tonkin

This study shows that Protein Kinase A (PKAc1) suppresses Ca2+ signalling in Toxoplasma gondii after host cell invasion, affecting motility and infectivity.

bioRxiv · Feb 14, 2018Microbiology