M. J. Davis

Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells

This study identifies lymphatic muscle cells as the pacemaker cells in mouse collecting lymphatic vessels through combined immunofluorescence, scRNA-seq, and electrophysiological analyses.

A dual-clock-driven model emulating the effects of either Ano1 or IP3R knock-out on lymphatic muscle cell pace-making

The paper develops a dual-clock model to simulate the effects of Ano1 or IP3R knock-out on lymphatic muscle cell pacemaking, improving accuracy by coupling M-clock and C-clock oscillators.

Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

This study shows that bariatric surgery followed by immune checkpoint blockade improves breast cancer outcomes in formerly obese mice, despite weight loss being less effective than diet in reducing tumor burden.

Modelling the coupling of the M-clock and C-clock in lymphatic muscle cells

The paper develops an in silico model of voltage and calcium oscillations in lymphatic muscle cells to better understand their excitation mechanisms and potential therapeutic targets.

Ex vivo Demonstration of Functional Deficiencies in Popliteal Lymphatic Vessels from TNF-Tg Mice with Inflammatory Arthritis

This study examines functional deficiencies in popliteal lymphatic vessels from TNF-Tg mice with inflammatory arthritis, showing reduced contraction and flow parameters that are partially reversible with NOS inhibition.

An Erg driven transcriptional program controls B-lymphopoiesis

This study identifies Erg as a critical transcription factor initiating B-lymphopoiesis by regulating gene networks essential for B-cell development and V(D)J recombination.

Snail induces epithelial cell extrusion through transcriptional control of RhoA contractile signalling and cell matrix adhesion

This study shows Snail induces cell extrusion through RhoA contractile signaling and reduced basal adhesion, independent of EMT.