Author

W. S. Alexander

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. J. Kueh· 2 shared A. P. Ng· 2 shared E. Leong· 2 shared J. J. Babon· 2 shared K. Doggett· 2 shared M. J. Herold· 2 shared N. J. Kershaw· 2 shared S. E. Nicholson· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

A. J. Kueh

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Author profile →

5 papers

Recent·Most cited

The SOCS1 KIR and SH2 domain are both required for suppression of cytokine signaling in vivo

K. Doggett, N. Keating, F. Dehkhoda, G. M. Bidgood, E. Leong, A. Kueh, N. A. Nicola, N. J. Kershaw, J. J. Babon, W. S. Alexander, S. E. Nicholson

This study shows that both the KIR and SH2 domains of SOCS1 are essential for its function in suppressing cytokine signaling, as mutations in either domain lead to neonatal lethality and inflammation.

bioRxiv · Dec 20, 2022 · PreprintCell Biology

SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine

K. Li, L. M. Guzman, L. Whitehead, E. Leong, A. J. Kueh, W. S. Alexander, N. J. Kershaw, J. J. Babon, K. Doggett, S. E. Nicholson

This study shows that SOCS2's regulation of growth hormone signaling depends on its interaction with phosphotyrosine, as demonstrated by comparing Socs2R96C/R96C and Socs2-/- mice.

bioRxiv · Jul 17, 2022Cell Biology

Iron homeostasis governs erythroid phenotype in Polycythemia Vera

C. Bennett, V. E. Jackson, A. Pettikiriarachchi, T. Hayman, U. Schaeper, G. Moir-Meyer, K. Fielding, R. Ataide, D. Clucas, A. Baldi, A. L. Garnham, C. S. Li-Wai-Suen, W. S. Alexander, M. Bahlo, K. Burbury, , S.-R. Pasricha

This study links iron homeostasis to Polycythemia Vera by showing HFE mutations affect hepcidin expression, which regulates erythroid phenotype.

bioRxiv · May 3, 2022 · PreprintCancer Biology

An Erg driven transcriptional program controls B-lymphopoiesis

A. P. Ng, H. D. Coughlan, S. Hediyeh-zadeh, K. Behrens, T. M. Johanson, M. S. Y. Low, C. C. Bell, O. Gilan, Y.-C. Chan, A. J. Kueh, T. Boudier, L. DiRago, C. D. Hyland, H. Ierino, S. Mifsud, , W. S. Alexander

This study identifies Erg as a critical transcription factor initiating B-lymphopoiesis by regulating gene networks essential for B-cell development and V(D)J recombination.

bioRxiv · Dec 3, 2019 · PreprintImmunology

miR17~92 is essential for the survival of hematopoietic stem and progenitor cells by restraining pro-apoptotic BIM

K. Brinkmann, C. Hyland, C. A. de Graaf, A. Strasser, W. S. Alexander, M. J. Herold

This study shows that miR17~92 is essential for hematopoietic stem and progenitor cell survival by suppressing the pro-apoptotic protein BIM.

bioRxiv · Jun 8, 2018Cell Biology