Author

M. J. Donnelly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 8 Ecology· 4 Zoology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Approach:statistical model· 7 Research Focus:host-pathogen & immune response· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:differential expression· 3 Organism:Drosophila· 3 Research Focus:gene regulatory network inference· 3 Assay:whole-genome sequencing· 3

Frequent Co-Authors

D. Weetman· 8 shared E. R. Lucas· 7 shared A. Miles· 4 shared A. Lynd· 3 shared A. Oruni· 3 shared C. S. Clarkson· 3 shared E. Ochomo· 3 shared L. S. Djogbenou· 3 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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8 shared papersEvolutionary Biology

D. Weetman

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Author profile →

14 papers

Recent·Most cited

Cryptic population structure and insecticide resistance in Anopheles gambiae from the southern Democratic Republic of Congo

T. P. W. Dennis, P. Pescod, S. Barasa, L. T. Cerdeira, E. R. Lucas, C. S. Clarkson, A. Miles, A. Asidi, E. Z. Manzambi, E. Metelo, J. Zanga, S. N. Salambi, S. R. Irish, M. J. Donnelly, D. Weetman, F. W. Tezzo

The paper investigates insecticide resistance and population structure in Anopheles gambiae from southern DRC, finding high resistance and genetic differentiation between populations.

bioRxiv · Mar 12, 2024 · PreprintEvolutionary Biology

Parallel evolution in mosquito vectors - a duplicated esterase locus is associated with resistance to pirimiphos-methyl in An. gambiae

S. C. Nagi, E. R. Lucas, A. Egyir-Yawson, J. Essandoh, S. Dadzie, J. Chabi, L. S. Djogbenou, A. A. Medjigbodo, C. V. Edi, G. Ketoh, B. G. Koudou, F. Ashraf, C. S. Clarkson, A. Miles, D. Weetman, M. J. Donnelly

This study identifies a duplicated esterase locus associated with pirimiphos-methyl resistance in Anopheles gambiae through population genomic analysis.

bioRxiv · Feb 1, 2024 · PreprintEvolutionary Biology

Spatially explicit sampling frameworks to identify regions of increased mosquito abundance

B. Kemei, E. Ochomo, M. Ombok, J. Midega, E. R. Lucas, M. J. Donnelly, L. Sedda, D. P. McDermott

This study applies a spatially explicit sampling framework in coastal Kenya to identify high mosquito abundance areas and improve vector control strategies.

bioRxiv · Nov 21, 2023 · PreprintEcology

Development and deployment of improved Anopheles gambiae s.l. field surveillance by adaptive spatial sampling design

G. M. Monteiro, L. S. Djogbenou, M. J. Donnelly, L. Sedda

This paper develops an adaptive spatial sampling design for malaria vector surveillance in Anopheles gambiae s.l., improving prediction accuracy while reducing sample size in high-risk areas.

bioRxiv · Jun 16, 2023 · PreprintEcology

The durability of long-lasting insecticidal nets treated with and without piperonyl butoxide (PBO) in Uganda.

F. Mechan, A. Katureebe, V. Tuhaise, M. Mugote, A. Oruni, I. Onyige, K. Bumali, J. Thornton, K. Maxwell, M. Kyohere, M. R. Kamya, P. Mutungi, S. P. Kigozi, A. Yeka, J. Opigo, , A. Lynd

This study compares the durability and bioefficacy of PBO-treated and pyrethroid-only LLINs in Uganda, finding that PBO content declines over time, reducing bioefficacy against resistant mosquitoes.

bioRxiv · Feb 17, 2022 · PreprintZoology

A gene expression panel for estimating age in males and females of the sleeping sickness vector Glossina morsitans

E. R. Lucas, A. C. Darby, S. J. Torr, M. J. Donnelly

The paper develops a gene expression panel to estimate age in tsetse flies, achieving accurate predictions with minimal gene markers.

bioRxiv · May 12, 2021Ecology

Identification of a rapidly-spreading triple mutant for high-level metabolic insecticide resistance in Anopheles gambiae provides a real-time molecular diagnostic for anti-malarial intervention deployment.

H. Njoroge, A. van't Hof, A. Oruni, D. Pipini, S. C. Nagi, A. Lynd, E. R. Lucas, S. Tomlinson, X. Grau-Bove, D. McDermott, F. t. Wat'senga, E. Z. Manzambi, F. R. Agossa, A. Mokuba, S. R. Irish, , M. J. Donnelly

The paper identifies a triple mutant in Anopheles gambiae associated with pyrethroid resistance and proposes it as a diagnostic for guiding anti-malarial intervention strategies.

bioRxiv · Feb 11, 2021 · PreprintEvolutionary Biology

Impact of vector control on effective population sizes; empirical evidence for a control- based genetic bottleneck in the tsetse fly Glossina fuscipes

A. Muhwezi, L. J. Cunningham, J. Esterhuizen, I. Tirados, E. Matovu, M. J. Donnelly, S. J. Torr

The paper assesses the impact of vector control on tsetse fly population genetics, finding a significant genetic bottleneck associated with control efforts.

bioRxiv · Jun 25, 2020 · PreprintEvolutionary Biology

Evolution of the insecticide target Rdl in African Anopheles is driven by interspecific andinterkaryotypic introgression

X. Grau-Bove, S. Tomlinson, A. O. O'Reilly, N. J. Harding, A. Miles, D. Kwiatkowski, M. J. Donnelly, D. Weetman, The Anopheles gambiae 1000 Genomes Consortium

The paper examines the evolution of insecticide resistance in Anopheles mosquitoes, showing how Rdl mutations spread through selective sweeps and introgression across species and karyotypes.

bioRxiv · Dec 17, 2019Evolutionary Biology

Open source 3D printable replacement parts for the WHO insecticide susceptibility bioassay system

S. Tomlinson, H. Carrington Yates, A. Oruni, H. N. Ng'ang'a, D. Weetman, M. J. Donnelly, A. E. Van't Hof

The paper provides 3D printable replacement parts for the WHO insecticide susceptibility bioassay system to address supply chain issues and enable rapid production.

bioRxiv · Sep 13, 2019Evolutionary Biology

A high throughput multi-locus insecticide resistance marker panel for tracking resistance emergence and spread in Anopheles gambiae

E. Lucas, K. A. Rockett, A. Lynd, J. Essandoh, N. Grisales, B. Kemei, H. Njoroge, C. Hubbart, E. J. Rippon, J. Morgan, A. Van't Hof, E. O. Ochomo, D. P. Kwiatkowski, D. Weetman, M. J. Donnelly

The paper develops a 28-marker genotyping panel to track insecticide resistance in Anopheles gambiae, identifying four resistance-associated mutations and geographic diversity in kdr resistance.

bioRxiv · Mar 31, 2019Evolutionary Biology

Analysis-ready datasets for insecticide resistance phenotype and genotype frequency in African malaria vectors

C. Moyes, A. Wiebe, K. Gleave, A. Trett, P. A. Hancock, G. G. Padonou, C. S. Mouhamadou, A. Sovi, S. A. Abuelmaali, E. Ochomo, C. Antonio-Nkondjio, D. Dengela, H. Kawada, R. K. Dabire, M. J. Donnelly, , M. Coleman

The paper provides analysis-ready, geospatial datasets on insecticide resistance in African malaria vectors to quantify resistance trends and assess their impact on malaria transmission.

bioRxiv · Mar 20, 2019Zoology

Improved spatial ecological sampling using open data and standardization: an example from malaria mosquito surveillance

L. Sedda, E. R. Lucas, L. S. Djogbenou, A. V. C. Edi, A. Egyr-Yawson, B. I. Kabula, J. Midega, E. Ochomo, D. Weetman, M. J. Donnelly

The paper proposes a framework for ecological sampling design using open data to improve malaria mosquito surveillance by balancing prediction accuracy and sample efficiency.

bioRxiv · Nov 9, 2018Ecology

Whole genome sequencing reveals high complexity of copy number variation at insecticide resistance loci in malaria mosquitoes

E. R. Lucas, A. Miles, N. J. Harding, C. S. Clarkson, M. K. N. Lawniczak, D. P. Kwiatkowski, D. Weetman, M. J. Donnelly, The Anopheles gambiae 1000 Genomes Consortium

The paper uses whole-genome sequencing to identify copy number variations (CNVs) in Anopheles gambiae linked to insecticide resistance, finding CNVs enriched for resistance-related genes and under positive selection.

bioRxiv · Aug 25, 2018Evolutionary Biology