Author

D. Weetman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 10 Ecology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Approach:statistical model· 6 Research Focus:host-pathogen & immune response· 4 Assay:whole-genome sequencing· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:gene regulatory network inference· 3 Organism:Arabidopsis· 2 Research Focus:differential expression· 2

Frequent Co-Authors

M. J. Donnelly· 8 shared E. R. Lucas· 5 shared A. Miles· 4 shared C. S. Clarkson· 3 shared J. Essandoh· 3 shared S. R. Irish· 3 shared S. Tomlinson· 3 shared A. Egyir-Yawson· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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Curved chords = mutual co-authorship

8 shared papersEvolutionary Biology

M. J. Donnelly

Mutual co-authors in cluster

Author profile →

13 papers

Recent·Most cited

Three years of insecticide resistance evolution and associated mechanisms in Aedes aegypti populations of Ouagadougou, Burkina Faso.

F. Yameogo, A. Sombie, M. Ote, E. Saiki, T. Sakurai, D. W. Wangrawa, P. J. McCall, D. Weetman, H. Kanuka, A. Badolo

This study tracks insecticide resistance in Aedes aegypti over three years in Burkina Faso, showing increasing resistance to pyrethroids linked to kdr mutations.

bioRxiv · Apr 9, 2024 · PreprintEvolutionary Biology

Cryptic population structure and insecticide resistance in Anopheles gambiae from the southern Democratic Republic of Congo

T. P. W. Dennis, P. Pescod, S. Barasa, L. T. Cerdeira, E. R. Lucas, C. S. Clarkson, A. Miles, A. Asidi, E. Z. Manzambi, E. Metelo, J. Zanga, S. N. Salambi, S. R. Irish, M. J. Donnelly, D. Weetman, F. W. Tezzo

The paper investigates insecticide resistance and population structure in Anopheles gambiae from southern DRC, finding high resistance and genetic differentiation between populations.

bioRxiv · Mar 12, 2024 · PreprintEvolutionary Biology

Parallel evolution in mosquito vectors - a duplicated esterase locus is associated with resistance to pirimiphos-methyl in An. gambiae

S. C. Nagi, E. R. Lucas, A. Egyir-Yawson, J. Essandoh, S. Dadzie, J. Chabi, L. S. Djogbenou, A. A. Medjigbodo, C. V. Edi, G. Ketoh, B. G. Koudou, F. Ashraf, C. S. Clarkson, A. Miles, D. Weetman, M. J. Donnelly

This study identifies a duplicated esterase locus associated with pirimiphos-methyl resistance in Anopheles gambiae through population genomic analysis.

bioRxiv · Feb 1, 2024 · PreprintEvolutionary Biology

Signatures of adaptation at key insecticide resistance loci in Anopheles gambiae in Southern Ghana revealed by low-coverage WGS.

T. P. W. Dennis, J. Essandoh, B. K. Mable, M. Viana, A. Egyir-Yawson, D. Weetman

This study uses low-coverage whole-genome sequencing to identify adaptation signatures at insecticide resistance loci in Anopheles mosquitoes in southern Ghana.

bioRxiv · Jan 17, 2024 · PreprintEvolutionary Biology

Insecticide resistance management strategies for public health control of mosquitoes exhibiting polygenic resistance: a comparison of sequences, rotations, and mixtures.

N. P. Hobbs, D. Weetman, I. Hastings

This paper compares insecticide resistance management strategies for mosquitoes with polygenic resistance, finding that full-dose mixtures extend strategy lifespan more than sequences or rotations.

bioRxiv · Oct 28, 2022Evolutionary Biology

Insecticide susceptibility of Aedes (Stegomyia) aegypti (Linnaeus, 1762) and Aedes (Stegomyia) albopictus (Skuse, 1894) in Kinshasa, Democratic Republic of the Congo

F. C. Z. Vulu, G. Ilombe, L. Vizcaino, J. Mariën, Y. Morimoto, D. Weetman, A. Lenhart, S. R. Irish, T. Bobanga

This study assesses insecticide susceptibility and kdr mutations in Aedes aegypti and Aedes albopictus in Kinshasa, finding resistance to deltamethrin and DDT in both species and the V410L kdr mutation in Ae. aegypti.

bioRxiv · Nov 8, 2021 · PreprintEcology

Identification of a rapidly-spreading triple mutant for high-level metabolic insecticide resistance in Anopheles gambiae provides a real-time molecular diagnostic for anti-malarial intervention deployment.

H. Njoroge, A. van't Hof, A. Oruni, D. Pipini, S. C. Nagi, A. Lynd, E. R. Lucas, S. Tomlinson, X. Grau-Bove, D. McDermott, F. t. Wat'senga, E. Z. Manzambi, F. R. Agossa, A. Mokuba, S. R. Irish, , M. J. Donnelly

The paper identifies a triple mutant in Anopheles gambiae associated with pyrethroid resistance and proposes it as a diagnostic for guiding anti-malarial intervention strategies.

bioRxiv · Feb 11, 2021 · PreprintEvolutionary Biology

Susceptibility status of larval Aedes aegypti mosquitoes in Saudi Arabia

A. M. Alnazawi, S. Ashall, D. Weetman

This study evaluates insecticide resistance in Ae. aegypti larvae from Saudi Arabia, finding full susceptibility to temephos and Bti, suggesting their use in dengue control.

bioRxiv · Dec 14, 2020 · PreprintCell Biology

Evolution of the insecticide target Rdl in African Anopheles is driven by interspecific andinterkaryotypic introgression

X. Grau-Bove, S. Tomlinson, A. O. O'Reilly, N. J. Harding, A. Miles, D. Kwiatkowski, M. J. Donnelly, D. Weetman, The Anopheles gambiae 1000 Genomes Consortium

The paper examines the evolution of insecticide resistance in Anopheles mosquitoes, showing how Rdl mutations spread through selective sweeps and introgression across species and karyotypes.

bioRxiv · Dec 17, 2019Evolutionary Biology

Open source 3D printable replacement parts for the WHO insecticide susceptibility bioassay system

S. Tomlinson, H. Carrington Yates, A. Oruni, H. N. Ng'ang'a, D. Weetman, M. J. Donnelly, A. E. Van't Hof

The paper provides 3D printable replacement parts for the WHO insecticide susceptibility bioassay system to address supply chain issues and enable rapid production.

bioRxiv · Sep 13, 2019Evolutionary Biology

A high throughput multi-locus insecticide resistance marker panel for tracking resistance emergence and spread in Anopheles gambiae

E. Lucas, K. A. Rockett, A. Lynd, J. Essandoh, N. Grisales, B. Kemei, H. Njoroge, C. Hubbart, E. J. Rippon, J. Morgan, A. Van't Hof, E. O. Ochomo, D. P. Kwiatkowski, D. Weetman, M. J. Donnelly

The paper develops a 28-marker genotyping panel to track insecticide resistance in Anopheles gambiae, identifying four resistance-associated mutations and geographic diversity in kdr resistance.

bioRxiv · Mar 31, 2019Evolutionary Biology

Improved spatial ecological sampling using open data and standardization: an example from malaria mosquito surveillance

L. Sedda, E. R. Lucas, L. S. Djogbenou, A. V. C. Edi, A. Egyr-Yawson, B. I. Kabula, J. Midega, E. Ochomo, D. Weetman, M. J. Donnelly

The paper proposes a framework for ecological sampling design using open data to improve malaria mosquito surveillance by balancing prediction accuracy and sample efficiency.

bioRxiv · Nov 9, 2018Ecology

Whole genome sequencing reveals high complexity of copy number variation at insecticide resistance loci in malaria mosquitoes

E. R. Lucas, A. Miles, N. J. Harding, C. S. Clarkson, M. K. N. Lawniczak, D. P. Kwiatkowski, D. Weetman, M. J. Donnelly, The Anopheles gambiae 1000 Genomes Consortium

The paper uses whole-genome sequencing to identify copy number variations (CNVs) in Anopheles gambiae linked to insecticide resistance, finding CNVs enriched for resistance-related genes and under positive selection.

bioRxiv · Aug 25, 2018Evolutionary Biology