D. E. Anderson

Replacement of tibialis cranialis tendon with polyester, silicone-coated artificial tendon preserves biomechanical function in rabbits

This study evaluates an artificial tendon in rabbits, finding it preserves biomechanical function compared to tendon excision.

Use of eVLP-based vaccine candidates to broaden immunity against SARS-CoV-2 variants

This study evaluates eVLP-based vaccine candidates against SARS-CoV-2 variants, showing that a trivalent vaccine induces broader immunity compared to single-variant vaccines.

An enveloped virus-like particle vaccine expressing a stabilized prefusion form of the SARS-CoV-2 spike protein elicits potent immunity after a single dose.

This paper evaluates an enveloped virus-like particle vaccine, VBI-2902a, which elicits strong immunity against SARS-CoV-2 after a single dose in mice and hamsters.

Next generation vaccine platform: polymersomes as stable nanocarriers for a highly immunogenic and durable SARS-CoV-2 spike protein subunit vaccine

This paper develops a subunit vaccine using polymersomes to deliver SARS-CoV-2 spike protein and CpG adjuvant, showing robust and durable immune responses in mice.

Orthogonal genome-wide screenings in bat cells identify MTHFD1 as a target of broad antiviral therapy

The paper identifies MTHFD1 as a target for broad antiviral therapy by screening bat cells with RNAi and CRISPR libraries against mumps and influenza viruses.

Genetic immunodeficiency and autoimmune disease reveal distinct roles of Hem1 in the WAVE2 and mTORC2 complexes

Hem1 loss-of-function mutations cause congenital immunodysregulation by disrupting WAVE2 and mTORC2 complexes, leading to immunodeficiency and immune hyperresponsiveness.

ENVELOPED VIRUS-LIKE PARTICLES (eVLPs) EXPRESSING MODIFIED FORMS OF ZIKA VIRUS PROTEINS E AND NS1 PROTECT MICE FROM ZIKA VIRUS INFECTION

This paper develops and tests bivalent eVLP vaccines expressing modified ZIKV E and NS1 proteins, showing 100% protection in mice against ZIKV challenge.