M. J. Previs

Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle

This study investigates the functional role of MyBP-H in developing vertebrate fast-twitch skeletal muscle using zebrafish and rat models, revealing its involvement in myofilament lattice compression and contractility regulation.

The Pathogenic R5L Mutation Disrupts Formation of Tau Complexes on the Microtubule by Altering Local N-Terminal Structure

This paper investigates the R5L mutation in Tau, showing it does not reduce microtubule-binding affinity but alters N-terminal structure, impairing Tau complex formation on microtubules.

The Skeletal Muscle Circadian Clock Regulates Titin Splicing Through RBM20

This study shows that the skeletal muscle circadian clock regulates titin splicing via RBM20, affecting sarcomere length and function.

Biomechanics and Myofibrillar Alignment Enhance Contractile Development and Reproducibility in Stem Cell Derived Cardiac Muscle

This study develops a 2D platform to enhance contractile development and reproducibility in stem cell-derived cardiac muscle by controlling biomechanics and myofibrillar alignment.

CryoEM Structure of Drosophila Flight Muscle Thick Filaments at 7A Resolution

The paper reports the 7Å resolution CryoEM structure of Drosophila flight muscle thick filaments, revealing conserved myosin tail arrangements and novel non-myosin densities.

SKELETAL MyBP-C ISOFORMS TUNE THE MOLECULAR CONTRACTILITY OF DIVERGENT SKELETAL MUSCLE SYSTEMS

This study examines how different MyBP-C isoforms affect contractility in fast- and slow-twitch skeletal muscles using proteomic, biophysical, and modeling approaches.

Single Molecule Visualization of Cardiac Myosin-Binding Protein C N-terminal Fragments Interacting with Thin Filaments: Mechanisms of Calcium Sensitization

This study uses single-molecule microscopy to show that the C0C3 fragment of cMyBP-C enhances myosin binding at low calcium but blocks it at high calcium, suggesting a role in calcium sensitization.