T. C. Bidone

Fascin structural plasticity mediates flexible actin bundle construction

This study investigates how fascin's structural plasticity enables flexible actin bundle formation through cryo-EM, tomography, and modeling.

A Parametric Blueprint for Optimum Cochlear Outer Hair Cell Design

This study identifies three universal ratios that optimize cochlear outer hair cell power conversion, independent of frequency and species.

Nascent adhesions differentially regulate lamellipodium velocity and persistence

The paper develops a computational model to study how actin and adhesions regulate cell migration, finding that actin polymerization drives protrusion while adhesion lifetime affects velocity and persistence.

Computational model of 3D cell migration based on the molecular clutch mechanism

The paper develops a computational model to study how ECM microstructure affects 3D cell migration through force-sensitive molecular clutches, finding that pore size and porosity influence migration speed.

Multiscale model of integrin adhesion assembly

The paper develops a computational model to study how integrin nanoscale properties influence adhesion assembly and stability.

Ena/VASP processive elongation is modulated by avidity on actin filaments bundled by the filopodia crosslinker fascin

This study shows Ena/VASP tetramers enhance processivity on fascin-bundled actin filaments through avidity, increasing run length with more filaments and arms.

The lamellipodium is a myosin independent mechanosensor

This paper shows that cell spreading on soft substrates is inhibited by reduced adhesion formation in the lamellipodium, independent of myosin II activity.