K. Costa

High-throughput genetics enables identification of nutrient utilization and accessory energy metabolism genes in a model methanogen

This paper uses high-throughput genetics to identify nutrient utilization and accessory energy metabolism genes in the methanogen Methanococcus maripaludis.

Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2

This study shows GBM cells use Plexin-B2 to regulate membrane tension and mechano-electrical coupling for migration through confined spaces.

Integrated omics analysis unveils a DNA damage response to neurogenic injury

The paper uses multi-omics analysis to study molecular changes in the bladder after spinal cord injury in rats and identifies DNA damage response pathways modulated by inosine treatment.

The fluorescence-activating and absorption-shifting tag (FAST) enables live-cell fluorescence imaging of Methanococcus maripaludis

The paper introduces FAST, a fluorescent tag that enables live-cell imaging of Methanococcus maripaludis under anoxic conditions, demonstrating its use for protein analysis and interactions.

Advanced understanding of prokaryotic biofilm formation using a cost-effective and versatile multi-panel adhesion (mPAD) mount

The paper introduces a 3D-printed mPAD mount for analyzing biofilm formation under varied conditions and shows phenazines are crucial for anoxic biofilm formation in Pseudomonas aeruginosa.

PPARdelta signaling activation improves metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.

This study shows that activating PPARD signaling enhances metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.

The mechanism of motor inhibition by microtubule-associated proteins

This study investigates how microtubule-associated proteins (MAPs) regulate motor protein interactions, finding that MAPs inhibit motors without blocking their binding sites and that motors must interact with MAPs to move on MAP-coated microtubules.

SARS CoV-2 nucleocapsid protein forms condensates with viral genomic RNA

This study shows that SARS-CoV-2 nucleocapsid protein forms condensates with viral RNA in vitro and in cells, driven by hydrophobic and electrostatic interactions.