Author

B. D. Pascal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Organism:yeast· 1

Frequent Co-Authors

A. L. Burlingame· 1 shared B. D. Schweibenz· 1 shared G. J. Narlikar· 1 shared J. D. Gross· 1 shared J. Zheng· 1 shared M. J. Trnka· 1 shared M. Solotchi· 1 shared P. Griffin· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

A. L. Burlingame

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2 papers

Recent·Most cited

RIG-I uses its intrinsically disordered CARDs-Helicase linker in RNA proofreading functions

B. D. Schweibenz, S. C. Devarkar, M. Solotchi, J. Zheng, B. D. Pascal, P. Griffin, S. S. Patel

This study identifies a proofreading mechanism in RIG-I that uses the CARDs-Helicase Linker to gate RNA specificity and stabilize interactions, preventing non-specific RNA engagement.

bioRxiv · Sep 23, 2021 · PreprintBiochemistry

Disorganization of the histone core promotes organization of heterochromatin into phase-separated droplets

S. Sanulli, M. J. Trnka, V. Dharmarajan, R. W. Tibble, B. D. Pascal, A. L. Burlingame, P. R. Griffin, J. D. Gross, G. J. Narlikar

This study shows that the S. pombe HP1 protein Swi6 promotes chromatin compaction through phase-separated droplets by disorganizing the histone core and increasing histone residue accessibility.

bioRxiv · Nov 18, 2018 · PreprintBiophysics