Author

M. K. Aghi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

S. Jain· 5 shared S. Kumar· 4 shared G. Yagnik· 3 shared A. Beniwal· 2 shared A. Chandra· 2 shared A. Diaz· 2 shared A. T. Nguyen· 2 shared E. A. Akins· 2 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersCancer Biology

S. Jain

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Viscoelastic high-molecular-weight hyaluronic acid hydrogels support rapid glioblastoma cell invasion with leader-follower dynamics

E. M. Carvalho, E. A. Ding, A. Saha, A. Weldy, P.-J. H. Zushin, A. Stahl, M. K. Aghi, S. Kumar

This study shows that high-molecular-weight hyaluronic acid hydrogels promote faster glioblastoma cell invasion with leader-follower dynamics compared to low-molecular-weight HA hydrogels.

bioRxiv · Apr 4, 2024Bioengineering

Dynamic fibroblast-immune interactions shape wound healing after brain injury

N. A. Ewing-Crystal, N. M. Mroz, A. A. Chang, E. D. Merrill, S. E. Caryotakis, L. Teo, A. Larpthaveesarp, T. Tsukui, A. Katewa, R. Pennington, G. L. McKinsey, S. Nelson, A. Ciesielska, M. W. Dahlgren, H. Paidassi, , A. B. Molofsky

This study identifies dynamic fibroblast-immune interactions that regulate CNS wound healing and neuroinflammation after brain injury.

bioRxiv · Mar 13, 2024Immunology

Glioma Cells Secrete Collagen VI to Facilitate Invasion

J. Cha, E. A. Ding, E. M. Carvalho, A. Fowler, M. K. Aghi, S. Kumar

This study identifies collagen VI secretion by glioma cells as a mechanism to remodel the microenvironment and promote invasion, particularly in bevacizumab-resistant tumors.

bioRxiv · Dec 12, 2023 · PreprintBioengineering

An engineered glioblastoma model yields novel macrophage-secreted drivers of invasion

E. A. Akins, D. Wilkins, M. K. Aghi, S. Kumar

The paper identifies BIGH3 as a macrophage-secreted driver of GBM invasion using a 3D model and shows its inhibition reduces GSC invasion.

bioRxiv · Nov 18, 2023Bioengineering

Glioblastoma induces the recruitment and differentiation of hybrid neutrophils from skull bone marrow

M. Lad, A. Beniwal, S. Jain, P. Shukla, J. Jung, S. Shah, G. Yagnik, H. Babikir, A. T. Nguyen, S. Gill, J. S. Young, A. Lui, D. Salha, A. Diaz, M. K. Aghi

This study identifies hybrid neutrophils with dendritic features in glioblastoma that suppress tumor growth and originate from skull bone marrow.

bioRxiv · Mar 24, 2023 · PreprintCancer Biology

Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterations

J. H. Garcia, E. A. Akins, S. Jain, K. J. Wolf, J. Zhang, N. Choudhary, M. Lad, P. Shukla, S. Gill, W. Carson, L. Carette, A. Zheng, S. Kumar, M. K. Aghi

This study identifies the transsulfuration pathway as a targetable metabolic driver of glioblastoma invasion through multi-omic analyses of engineered biomaterials and patient biopsies.

bioRxiv · Feb 23, 2023 · PreprintCancer Biology

Identification of Cancer-Associated Fibroblasts in Glioblastoma and Defining Their Pro-tumoral Effects

S. Jain, J. Rick, R. Joshi, A. Beniwal, J. Spatz, A. C.-C. Chang, A. T. Nguyen, S. Sudhir, A. Chandra, A. Haddad, H. Wadhwa, S. S. Shah, S. Choi, J. L. Hayes, L. Wang, , M. K. Aghi

The paper identifies cancer-associated fibroblasts in glioblastoma and shows their pro-tumoral effects through interactions with glioblastoma stem cells.

bioRxiv · May 8, 2021 · PreprintCancer Biology

Role of c-Met/β1 integrin complex in the metastatic cascade

D. Lau, H. Wadhwa, S. Sudhir, S. Jain, A. Chandra, A. Nguyen, J. Spatz, S. S. Shah, J. Cheng, M. Safaee, G. Yagnik, A. Jahangiri, M. K. Aghi

This study identifies the c-Met/β1 integrin complex as a driver of breast cancer intravasation and bone metastasis, suggesting therapeutic targeting could prevent metastases.

bioRxiv · Apr 20, 2020 · PreprintCancer Biology