Author

J. Spatz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

A. Chandra· 2 shared C. Schaffitzel· 2 shared F. Garzoni· 2 shared G. Yagnik· 2 shared H. Wadhwa· 2 shared I. Berger· 2 shared J. Capin· 2 shared K. Gupta· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. Chandra

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Antibodies generated in vitro and in vivo elucidate design of a thermostable ADDomer COVID-19 nasal nanoparticle vaccine

D. Buzas, H. A. Bunzel, O. Staufer, E. Milodowski, G. Edmonds, J. Bufton, B. Vidana Matteo, S. Yadav, K. Gupta, C. Fletcher, M. Kavanagh Williamson, A. Harrison, U. Borucu, J. Capin, O. Francis, , I. Berger

This study develops a thermostable ADDomer-based nanoparticle vaccine that neutralizes SARS-CoV-2 and cross-reacts with VOCs, demonstrating its potential for nasal administration.

bioRxiv · Mar 17, 2023Biochemistry

Binding of His-tagged fluorophores to lipid bilayers and giant vesicles

S. Pramanik, J. Steinkuehler, R. Dimova, J. Spatz, R. Lipowsky

The paper studies the binding of His-tagged fluorophores to lipid bilayers and giant vesicles, finding that 6H-FITC is quenched by anchor lipids and has a lower dissociation constant than 6H-GFP.

bioRxiv · Feb 1, 2022Biophysics

Identification of Cancer-Associated Fibroblasts in Glioblastoma and Defining Their Pro-tumoral Effects

S. Jain, J. Rick, R. Joshi, A. Beniwal, J. Spatz, A. C.-C. Chang, A. T. Nguyen, S. Sudhir, A. Chandra, A. Haddad, H. Wadhwa, S. S. Shah, S. Choi, J. L. Hayes, L. Wang, , M. K. Aghi

The paper identifies cancer-associated fibroblasts in glioblastoma and shows their pro-tumoral effects through interactions with glioblastoma stem cells.

bioRxiv · May 8, 2021 · PreprintCancer Biology

Unexpected free fatty acid binding pocket in the cryo-EM structure of SARS-CoV-2 spike protein

C. Toelzer, K. Gupta, S. K. Yadav, U. Borucu, F. Garzoni, O. Staufer, J. Capin, J. Spatz, D. Fitzgerald, I. Berger, C. Schaffitzel

The paper reveals a direct structural link between SARS-CoV-2 spike protein and linoleic acid, a key molecule in inflammation, immune modulation, and membrane fluidity.

bioRxiv · Jun 18, 2020Biochemistry

Substrate Resistance to Traction Forces Controls Fibroblast Polarization

D. Missirlis, L. Heckmann, T. Haraszti, J. Spatz

This study shows that fibroblast polarization depends on substrate stiffness to resist traction forces, while spreading depends on a stiff surface layer.

bioRxiv · May 15, 2020Biophysics

Role of c-Met/β1 integrin complex in the metastatic cascade

D. Lau, H. Wadhwa, S. Sudhir, S. Jain, A. Chandra, A. Nguyen, J. Spatz, S. S. Shah, J. Cheng, M. Safaee, G. Yagnik, A. Jahangiri, M. K. Aghi

This study identifies the c-Met/β1 integrin complex as a driver of breast cancer intravasation and bone metastasis, suggesting therapeutic targeting could prevent metastases.

bioRxiv · Apr 20, 2020 · PreprintCancer Biology