A. Diaz

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens

The paper identifies tumor-wide splicing aberrations that generate public neoantigens, enabling T-cell-based immunotherapies targeting intratumoral heterogeneity.

Risk of urban Mayaro virus (Alphavirus: Togaviridae) transmission: is Aedes aegypti a competent vector?

This study assesses the competence of Aedes aegypti mosquitoes as vectors for Mayaro virus, finding they require higher viral doses than humans can produce to transmit the virus effectively.

Distinct human stem cell subpopulations drive adipogenesis and fibrosis in musculoskeletal injury

The paper identifies distinct FAP subpopulations in human musculoskeletal injuries that drive adipogenesis and fibrosis, showing that DLK1 downregulation promotes degeneration.

Effects of blood meal source and seasonality on reproductive traits of Culex quinquefasciatus (Diptera: Culicidae)

This study examines how blood meal source and seasonality affect reproductive traits of Culex quinquefasciatus, finding significant interaction effects on fecundity and fertility.

Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy

This study shows Nrf1 promotes autophagy in response to proteotoxic stress, enhancing cell survival by upregulating autophagy pathway components.

Jamestown Canyon Virus is transmissible by Aedes aegypti and is only moderately blocked by Wolbachia co-infection

This study shows that Aedes aegypti can transmit Jamestown Canyon Virus (JCV) and that Wolbachia only moderately blocks JCV replication, suggesting distinct mechanisms for blocking negative-sense vs. positive-sense viruses.

Glioblastoma induces the recruitment and differentiation of hybrid neutrophils from skull bone marrow

This study identifies hybrid neutrophils with dendritic features in glioblastoma that suppress tumor growth and originate from skull bone marrow.

Ecological and life-history traits and their relationship with West Nile virus and Saint Louis Encephalitis virus exposure risk.

The paper examines how ecological and life-history traits of birds influence exposure risk to West Nile virus and Saint Louis Encephalitis virus.

Mucins shed from the laminated layer in cystic echinococcosis are captured by Kupffer cells via the lectin receptor Clec4F

The paper shows that mucins from the laminated layer of E. granulosus are captured by Kupffer cells via Clec4F, highlighting a mechanism for host clearance of parasite-derived materials.

Neotropical birds and mammals show divergent behaviour responses to human pressure

The paper examines diel activity changes in Neotropical birds and mammals under varying human pressure, finding mammals become more nocturnal and birds more diurnal.

Evolution of CRISPR-associated Endonucleases as Inferred from Resurrected Proteins

This study resurrects ancient CRISPR-Cas9 nucleases to show their greater flexibility in PAM and gRNA requirements and their evolution toward double-strand break activity.

Linking functional traits with tree growth and forest productivity in Quercus ilex forests along a climatic gradient

The paper examines how functional traits influence tree growth and forest productivity in Quercus ilex forests across a climatic gradient.

Identification of Cancer-Associated Fibroblasts in Glioblastoma and Defining Their Pro-tumoral Effects

The paper identifies cancer-associated fibroblasts in glioblastoma and shows their pro-tumoral effects through interactions with glioblastoma stem cells.

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

The paper identifies dominant immune system archetypes across 364 tumors from 12 cancer types using flow cytometry and transcriptomic data, linking them to tumor biology classifications.

High-resolution synchrotron imaging studies of intact fresh roots reveal soil bacteria promoted bioremediation and bio-fortification

The paper uses high-resolution imaging to show soil bacteria enhance metal uptake in Arabidopsis roots, promoting bioremediation and biofortification.

Culex saltanensis and Culex interfor (Diptera: Culicidae) are susceptible and competent to transmit St. Louis encephalitis virus (Flavivirus: Flaviviridae) in central Argentina.

This study shows that Culex saltanensis and Culex interfor can transmit St. Louis encephalitis virus in central Argentina, similar to Culex pipiens quinquefasciatus.

Does women’s interpersonal anxiety track changes in steroid hormone levels?

This study investigates whether women's interpersonal anxiety tracks changes in steroid hormone levels during the menstrual cycle and finds no evidence for progesterone's role, though some cortisol-related jealousy components are observed.

A draft single-cell atlas of human glioblastoma reveals a single axis of phenotype in tumor-propagating cells.

This study constructs a single-cell atlas of human glioblastoma, revealing a single axis of variation in tumor-propagating cells and linking mesenchymal GSCs to poor prognosis.