M. K. MacLeod

Lung influenza virus specific memory CD4 T cell location and optimal cytokine production are dependent on interactions with lung antigen-presenting cells

Triphasic production of IFNγ by innate and adaptive lymphocytes following influenza A virus infection

This study identifies a triphasic production of IFNγ by different immune cell types during and after influenza A virus infection, highlighting memory-like phenotypes in some cells.

Enhanced survival and low proliferation marks multifunctional virus specific memory CD4 T cells

The paper identifies multifunctional virus-specific memory CD4 T cells that exhibit enhanced survival and low proliferation, suggesting survival, not proliferation, drives their persistence in the memory pool.

Low-dose lung radiotherapy for COVID-19 lung disease: a pre-clinical efficacy study in a bleomycin model of pneumonitis.

This study evaluates low-dose lung radiotherapy (LDLR) in a bleomycin pneumonitis model, finding that 1.0 Gy LDLR improves recovery and reduces inflammation, particularly in moderate cases.

Tolerance induction in memory CD4 T cells is partial and reversible

This study shows that memory CD4 T cells can partially tolerate antigen re-exposure but can be reversed by adjuvant-containing reactivation.