Author

K. E. Hargrave

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. C. Worrell· 3 shared M. K. MacLeod· 3 shared T. Purnell· 3 shared M. K. L. MacLeod· 2 shared A. Masdefiol Garriga· 1 shared A. Taggart· 1 shared A. Wickenhagen· 1 shared C. Boutell· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

J. C. Worrell

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Ovothiol is a redundant part of a complex thiol network in promastigote Leishmania mexicana

V. L. Bolton, L. L. Morrison, S. Khanra, R. Ritchie, K. E. Hargrave, R. J. S. Burchmore, M. K. L. MacLeod, M. P. Barrett

This paper shows that OvoA, an enzyme involved in ovothiol synthesis in Leishmania mexicana, is not essential for growth or infectivity but affects sensitivity to amphotericin B.

bioRxiv · Dec 8, 2023 · PreprintBiochemistry

Lung influenza virus specific memory CD4 T cell location and optimal cytokine production are dependent on interactions with lung antigen-presenting cells

K. E. Hargrave, J. C. Worrell, C. Pirillo, E. Brennan, A. Masdefiol Garriga, J. I. Gray, T. Purnell, E. W. Roberts, M. K. MacLeod

bioRxiv · Sep 19, 2023Immunology

Triphasic production of IFNγ by innate and adaptive lymphocytes following influenza A virus infection

G. E. Finney, K. E. Hargrave, M. Pingen, T. Purnell, D. Todd, F. MacDonald, J. C. Worrell, M. K. MacLeod

This study identifies a triphasic production of IFNγ by different immune cell types during and after influenza A virus infection, highlighting memory-like phenotypes in some cells.

bioRxiv · May 23, 2023Immunology

Enhanced survival and low proliferation marks multifunctional virus specific memory CD4 T cells

L. M. Westerhof, J. Noonan, K. E. Hargrave, E. T. Chimbayo, Z. Cheng, T. Purnell, M. R. Jackson, N. Borcherding, M. K. MacLeod

The paper identifies multifunctional virus-specific memory CD4 T cells that exhibit enhanced survival and low proliferation, suggesting survival, not proliferation, drives their persistence in the memory pool.

bioRxiv · Dec 13, 2022 · PreprintImmunology

Zoonotic avian influenza viruses evade human BTN3A3 restriction

R. M. Pinto, S. Bakshi, S. Lytras, M. K. Zakaria, S. Swingler, J. C. Worrell, V. Herder, M. Varjak, N. Cameron-Ruiz, M. Collados-Rodriguez, M. Varela, A. Wickenhagen, C. Loney, Y. Pei, J. Hughes, , M. Palmarini

This study identifies BTN3A3 as a human restriction factor that inhibits avian influenza viruses but not human IAVs, with resistance linked to specific NP mutations.

bioRxiv · Jun 14, 2022 · PreprintMicrobiology