M. Grandoch

Collagen receptor GPVI-mediated platelet activation and pro-coagulant activity aggravates inflammation and aortic wall remodelling in abdominal aortic aneurysm

This study shows that GPVI-mediated platelet activation worsens AAA by promoting inflammation and aortic wall remodeling, suggesting GPVI as a therapeutic target.

Inhibition of hyaluronan synthesis prevents β-cell loss in obesity-associated type 2 diabetes

This study shows that inhibiting hyaluronan synthesis with 4-MU prevents β-cell loss in obesity-associated type 2 diabetes by increasing survivin expression and blocking apoptosis.

PI 3-kinase isoform p110α mediated FOXO1 inactivation protects against aortic aneurysm formation

This study shows that p110α-mediated FOXO1 inactivation in smooth muscle cells prevents aortic aneurysm formation by maintaining vascular homeostasis and promoting reparative SMC phenotypes.

Deficiency in hyaluronan synthase 3 attenuates ruptures in a murine model of abdominal aortic aneurysms by reduced aortic monocyte infiltration

This study shows that deficiency in HAS3 reduces aortic ruptures in a murine AAA model by decreasing monocyte infiltration and ECM degradation.

Targeting of MMP-13 prevents aortic aneurysm formation in Marfan mice

This study shows that targeting MMP-13 prevents aortic aneurysm formation in Marfan mice by reducing collagen degradation and BMP activity.

Single-cell transcriptomics defines heterogeneity of epicardial cells and fibroblasts within the infarcted heart

The paper uses single-cell RNA sequencing to identify distinct epicardial stromal cell populations in infarcted mouse hearts and their potential cardiomyogenic properties.