Author

M. L. Insco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:zebrafish· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

B. J. Abraham· 2 shared C. G. Ludwig· 2 shared C. Wu· 2 shared D. Liu· 2 shared K. Y. Chen· 2 shared L. I. Zon· 2 shared A. Dedeilia· 1 shared A. M. Cox· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

B. J. Abraham

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2 papers

Recent·Most cited

Specific oncogene activation of the cell of origin in mucosal melanoma

S. Babu, J. Chen, E. Robitschek, C. S. Baron, A. McConnell, C. Wu, A. Dedeilia, M. Sade-Feldman, R. Modhurima, M. P. Manos, K. Y. Chen, A. M. Cox, C. G. Ludwig, J. Yang, M. Kellis, , M. L. Insco

This study develops a zebrafish model of mucosal melanoma by activating an oncogene and inactivating tumor suppressors, revealing that internal melanocytes give rise to tumors with distinct transcriptional and chromatin features.

bioRxiv · Apr 22, 2024Cancer Biology

CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts

M. L. Insco, B. J. Abraham, S. J. Dubbury, S. Dust, C. Wu, K. Y. Chen, D. Liu, C. G. Ludwig, S. Bellaousov, T. Fabo, T. Henriques, K. Adelman, M. Geyer, P. A. Sharp, R. A. Young, , L. I. Zon

This study identifies CDK13 mutations in melanoma, showing they lead to accumulation of truncated transcripts and poor survival, with a mechanism involving impaired ZC3H14 phosphorylation and PAXT complex recruitment.

bioRxiv · Nov 5, 2019Biophysics