S. Babu

Specific oncogene activation of the cell of origin in mucosal melanoma

This study develops a zebrafish model of mucosal melanoma by activating an oncogene and inactivating tumor suppressors, revealing that internal melanocytes give rise to tumors with distinct transcriptional and chromatin features.

Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

This study identifies IL-17 and COX2 as negative regulators of protective immunity in tuberculosis, showing that Ly6G+ granulocytes are a major source of IL-17 and their inhibition reduces bacterial burden and pathology.

Rice WRKY13 TF protein binds to motifs in the promoter region to regulate downstream disease resistance-related genes

This study identifies downstream genes regulated by WRKY13 TF in rice through promoter analysis, motif detection, and molecular docking, revealing its role in disease resistance.

Quantifying the Invasive Secondary Metabolome

The paper quantifies invasive secondary metabolomes in plant species to test hypotheses about invasive plant competitiveness.

Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina

This study shows Banp is essential for DNA damage response and chromosome segregation in zebrafish retina, preventing mitotic defects and apoptosis.

Dry heat sterilization as a method to recycle N95 respirator masks: the importance of fit

This study shows that dry heat decontaminates N95 respirators and preserves their fit, unlike autoclaving which compromises fit and makes them unusable.

A Cyclic Phosphoramidate Prodrug of 2-deoxy-2-fluoro-2-C-methylguanosine for the Treatment of Dengue Infection

This paper identifies a cyclic phosphoramidate prodrug that shows anti-dengue activity in vitro and in vivo but is suspended due to toxicity concerns.

Decision Support Systems based on Scientific Evidence: Bibliometric Networks of Invasive Lantana camara.

This paper introduces a bibliometric data analysis protocol using a Decision Support System to explore research themes, demonstrated with a case study on Lantana camara.

Aging increases the systemic molecular degree of inflammatory perturbation in patients with tuberculosis

This study finds that aging increases the molecular degree of inflammatory perturbation in tuberculosis patients, with higher values observed in adults compared to children.

An unbiased high-throughput drug screen reveals a potential therapeutic vulnerability in the most lethal molecular subtype of pancreatic cancer

This study identifies K17 as a biomarker for PDAC and shows that PPT, a microtubule inhibitor, is more effective against K17-expressing PDAC cells when combined with Gemcitabine.

Staphylococcus pasteuri isolates (Spvs) from human atherosclerotic plaques mediate virulence, intracellular resistance and transendothelial invasion of macrophages: A mechanistic paradigm for microbial pathogenicity in atherosclerosis

This study identifies Staphylococcus pasteuri in atherosclerotic plaques and shows it can survive phagocytosis, activate macrophages, and induce transendothelial migration via CCL1-CCR8.