Author

L. I. Zon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:zebrafish· 3 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

S. Yang· 2 shared T. Fabo· 2 shared A. M. McConnell· 1 shared A. Narla· 1 shared A. Thomas· 1 shared B. J. Abraham· 1 shared B. J. Barnes· 1 shared B. M. Dulmovits· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

S. Yang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma

H. R. Noonan, J. Barbano, M. Xifaras, C. S. Baron, S. Yang, K. Koczirka, A. M. McConnell, L. I. Zon

The paper identifies a TGFb-induced immune response in melanoma using a zebrafish reporter and shows the need for chronic TGFb biomarkers.

bioRxiv · Sep 29, 2022Cancer Biology

Limb Specific Failure of Proliferation and Translation in the Mesenchyme Leads to Skeletal Defects in Diamond Blackfan Anemia

J. Hom, T. Karnavas, E. Hartman, J. Papoin, Y. Tang, B. M. Dulmovits, M. Khan, H. Patel, J. Bondy, M. Edelman, R. Touraine, G. Chanoz-Poulard, G. Ottenberg, R. Maynard, D. J. Adams, , L. Blanc

This study identifies site-specific skeletal defects in DBA by showing limb-specific mesenchymal stem cell proliferation and translation failures linked to WNT signaling and p53.

bioRxiv · Jan 14, 2022 · PreprintCell Biology

SATB2 induction of a neural crest mesenchyme-like program drives invasion and drug resistance in melanoma

M. Fazio, E. van Rooijen, M. Dang, G. van de Hoek, J. Ablain, J. K. Mito, S. Yang, A. Thomas, J. Michael, T. Fabo, R. Modhurima, P. Pessina, C. K. Kaufman, Y. Zhou, R. M. White, L. I. Zon

This study shows SATB2 drives melanoma invasion and drug resistance by inducing a neural crest mesenchyme-like transcriptional program in zebrafish and human models.

bioRxiv · Nov 1, 2020Cancer Biology

CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts

M. L. Insco, B. J. Abraham, S. J. Dubbury, S. Dust, C. Wu, K. Y. Chen, D. Liu, C. G. Ludwig, S. Bellaousov, T. Fabo, T. Henriques, K. Adelman, M. Geyer, P. A. Sharp, R. A. Young, , L. I. Zon

This study identifies CDK13 mutations in melanoma, showing they lead to accumulation of truncated transcripts and poor survival, with a mechanism involving impaired ZC3H14 phosphorylation and PAXT complex recruitment.

bioRxiv · Nov 5, 2019Biophysics