Author

K. Y. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. H. Lippert· 1 shared A. M. Santos· 1 shared A. M. Tate· 1 shared A. Winkel· 1 shared B. J. Abraham· 1 shared C. G. Ludwig· 1 shared C. Wu· 1 shared D. Klenerman· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperBiophysics

A. H. Lippert

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Author profile →

5 papers

Recent·Most cited

Robust T-cell signaling triggered on soft polydimethylsiloxane-supported lipid-bilayers

A. H. Lippert, I. B. Dimov, A. Winkel, J. McColl, J. Humphrey, K. Y. Chen, A. M. Santos, E. Jenkins, K. Franze, S. Davis, D. Klenerman

This study investigates T-cell signaling on soft lipid bilayers, finding early calcium signaling is not mechanosensitive but phosphatase exclusion occurs on soft substrates.

bioRxiv · Jun 5, 2020 · PreprintBiophysics

CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts

M. L. Insco, B. J. Abraham, S. J. Dubbury, S. Dust, C. Wu, K. Y. Chen, D. Liu, C. G. Ludwig, S. Bellaousov, T. Fabo, T. Henriques, K. Adelman, M. Geyer, P. A. Sharp, R. A. Young, , L. I. Zon

This study identifies CDK13 mutations in melanoma, showing they lead to accumulation of truncated transcripts and poor survival, with a mechanism involving impaired ZC3H14 phosphorylation and PAXT complex recruitment.

bioRxiv · Nov 5, 2019Biophysics

Nanoaperture fabrication via colloidal lithography for single molecule fluorescence imaging

R. M. Jamiolkowski, K. Y. Chen, S. A. Fiorenza, A. M. Tate, S. H. Pfeil, Y. E. Goldman

This paper describes a method to fabricate zero-mode waveguides (ZMWs) using colloidal lithography, enabling single molecule fluorescence imaging without requiring expensive equipment.

bioRxiv · May 3, 2019Biophysics

Methodologic Issues in Doubly Labeled Water Measurements of Energy Expenditure During Very Low-Carbohydrate Diets

K. D. Hall, J. Guo, K. Y. Chen, R. L. Leibel, M. L. Reitman, M. Rosenbaum, S. R. Smith, E. Ravussin

This study compares energy expenditure measurements using doubly labeled water (DLW) and respiratory chambers during very low-carbohydrate diets, finding that DLW overestimates energy expenditure when not adjusted for respiratory quotient changes.

bioRxiv · Oct 23, 2018Physiology

Stochastic Simulation to Visualize Gene Expression and Error Correction in Living Cells

K. Y. Chen, D. M. Zuckerman, P. C. Nelson

The paper demonstrates stochastic simulation for visualizing gene expression and error correction in cells, using case studies and code samples for educational purposes.

bioRxiv · Sep 15, 2018Biophysics