Author

M. Manfredi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Ali· 1 shared A. Bleve· 1 shared A. Friedman· 1 shared A. Luengo· 1 shared A. Plasger· 1 shared A. Polverari· 1 shared A. Sica· 1 shared B. Ngo· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. Ali

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

RORγ bridges cancer-driven lipid dysmetabolism and myeloid immunosuppression

A. Bleve, F. M. Consonni, M. Incerti, V. Garlatti, C. Pandolfo, M. N. Monari, S. Serio, D. Pistillo, M. Sironi, C. Ali, M. Manfredi, G. Finocchiaro, C. Panico, G. Condorelli, A. Sica

This study shows RORγ mediates cancer-driven lipid dysmetabolism and myeloid immunosuppression by promoting MDSC expansion and M2 TAM polarization, with cholesterol lowering reversing these effects.

bioRxiv · Nov 19, 2023Immunology

Plant signals anticipate the induction of the type III secretion system in Pseudomonas syringae pv. actinidiae facilitating efficient temperature-dependent effector translocation

M. R. Puttilli, D. Danzi, C. Correia, J. Brandi, D. Cecconi, M. Manfredi, E. Marengo, C. Santos, F. Spinelli, A. Polverari, E. VANDELLE

The paper shows plant signals and temperature regulate the timing of bacterial virulence in Pseudomonas syringae, influencing effector translocation and disease outcome.

bioRxiv · Jun 1, 2022Microbiology

Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis

B. Ngo, E. Kim, V. Osorio-Vasquez, S. Doll, S. Bustraan, A. Luengo, S. M. Davidson, A. Ali, G. D. Ferraro, D. Kang, J. Ni, R. Liang, A. Plasger, E. R. Kastenhuber, R. Eskandari, , M. E. Pacold

This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.

bioRxiv · Mar 3, 2020 · PreprintCancer Biology