M. Manzano

Intrinsic p53 Activation Restricts Gammaherpesvirus-Driven Germinal Center B Cell Expansion during Latency Establishment

This study shows that p53 activation restricts MHV68-driven GC B cell expansion during latency, with M2 and LMP1 triggering p53-dependent anti-proliferative responses.

Expression Ratios of the Anti-Apoptotic BCL2 Family Members Dictate the Selective Addiction of KSHV-Transformed Primary Effusion Lymphoma Cell Lines to MCL1

This study shows that PEL cells depend on MCL1 for survival due to its higher expression compared to other BCL2 family members, and suggests caution in using MCL1 inhibitors as monotherapy.

CRISPR Screens Identify Novel Regulators of cFLIP Dependency and Ligand-Independent, TRAIL-R1-Mediated Cell Death

The paper identifies novel regulators of cFLIP dependency and ligand-independent TRAIL-R1-mediated cell death in PEL cells using CRISPR screens and functional experiments.

Highly Sensitive Detection of Campylobacter spp. in Chicken Meat using a Silica Nanoparticle Enhanced Dot Blot DNA Biosensor

This paper develops a silica nanoparticle-enhanced dot blot biosensor for highly sensitive detection of Campylobacter in chicken meat without PCR.

The oncogenic Kaposi sarcoma-associated herpesvirus encodes a mimic of the tumor suppressive miR-15/16 miRNA family

This study identifies KSHV miR-K6-5p as a functional mimic of the tumor suppressive miR-15/16 family, showing it inhibits cell cycle progression and promotes growth in KSHV-transformed B cells.

Genome-wide CRISPR Screens Reveal Genetic Mediators of Cereblon Modulator Toxicity in Primary Effusion Lymphoma

The paper uses CRISPR screens to identify genetic mediators of cereblon modulator toxicity in primary effusion lymphoma, finding that CRBN and UBE2G1 inactivation confer resistance to different CMs.