M. Nakao

Multiple HP1 binding motifs in SUV420H2 heterochromatic targeting module

This study identifies three HP1 binding motifs in SUV420H2's HTM, showing that the second motif is critical for stabilizing HP1 on heterochromatin.

ROR1 plays a critical role in pancreatic tumor-initiating cells with a partial EMT signature.

This study identifies ROR1 as a critical marker for pancreatic tumor-initiating cells with a partial EMT signature, showing its role in promoting tumor growth and relapse.

Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response

This study identifies ULK1 as the kinase responsible for phosphorylating p62, which activates NRF2 in a redox-independent manner through retention of KEAP1 in p62 bodies.

LSD1 acts as an epigenetic barrier against glucocorticoid-induced atrophy and exercise-induced hypertrophy in skeletal muscle

This study shows LSD1 regulates fiber type-specific responses to stress in skeletal muscle by modulating gene expression through epigenetic mechanisms.

Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms

This study shows Ki-67 and condensins have independent yet cooperative roles in maintaining mitotic chromosome structure through distinct mechanisms.