M. G. Shapiro

Directed Evolution of Acoustic Reporter Genes Using High-Throughput Acoustic Screening

The paper evolves acoustic reporter genes using high-throughput acoustic screening to enhance nonlinear ultrasound scattering.

Ultrasonic reporters of calcium for deep tissue imaging of cellular signals

This paper introduces a genetically encoded ultrasonic calcium reporter (URoC) for noninvasive in vivo imaging of calcium signaling in mammals.

Geometric effects in gas vesicle buckling under ultrasound

This study investigates how the geometry of gas vesicles affects their buckling behavior under ultrasound, showing diameter has an inverse cubic effect on buckling pressure while length has minimal impact.

Magneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo

This paper introduces magneto-gas vesicles (MGVs) for non-invasive in vivo imaging of tissue mechanics, showing improved sensitivity and resolution compared to existing methods.

Smart sealants for prevention and monitoring of gastrointestinal anastomotic leaks using portable smartphone-controlled ultrasound transducers

This paper presents a smart hydrogel patch for sealing and early detection of gastrointestinal anastomotic leaks using ultrasound imaging and pH/enzyme-responsive sensors.

Doppler Slicing for Ultrasound Super-Resolution Without Contrast Agents

This paper introduces Doppler Slicing, a method to achieve super-resolution ultrasound imaging of vascular structures without contrast agents by using Fourier decomposition and compressed sensing.

Engineering Viral Vectors for Acoustically Targeted Gene Delivery

This study engineers AAV vectors for acoustically targeted gene delivery, improving specificity and efficiency while reducing peripheral transduction.

Ultrafast amplitude modulation for molecular and hemodynamic ultrasound imaging

This paper introduces an ultrafast nonlinear ultrasound imaging technique that improves sensitivity, field of view, and frame rate for molecular and hemodynamic imaging.

Genomically mined acoustic reporter genes enable real-time in vivo monitoring of tumors and tumor-homing probiotics

The paper develops improved acoustic reporter genes for real-time in vivo tumor and therapeutic bacteria monitoring in mouse models.

Measuring gas vesicle dimensions by electron microscopy

The paper explains discrepancies in gas vesicle diameter measurements and provides accurate methods using electron microscopy.

Thermal Control of T-cell Immunotherapy

This paper develops genetic circuits in T-cells that can be activated by temperature, enabling controlled immunotherapy with reduced off-target effects.

Transcranial Focused Ultrasound Generates Skull-Conducted Shear Waves: Computational Model and Implications for Neuromodulation

This study models shear wave propagation in the human skull caused by transcranial focused ultrasound and shows it can affect off-target structures like the cochlea.

Genetically encoded phase contrast agents for digital holographic microscopy

This paper introduces genetically encoded phase contrast agents using gas vesicles for digital holographic microscopy, enabling tracking of bacteria and imaging of mammalian cell uptake.

Selective Ablation of Cancer Cells with Low Intensity Pulsed Ultrasound

This study demonstrates that low intensity pulsed ultrasound selectively disrupts cancer cells by exploiting their distinct mechanical properties, offering a safer alternative to high intensity ultrasound ablation.

Genetically encoded nanostructures enable acoustic manipulation of engineered cells

This paper demonstrates that genetically encoded gas vesicles can be manipulated by ultrasound to control engineered cells.

Acoustically Detonated Biomolecules for Genetically Encodable Inertial Cavitation

This paper demonstrates the use of gas vesicles engineered to produce mechanical effects via ultrasound, enabling targeted cell lysis and therapeutic payload release in vitro, in cellulo, and in vivo.

Biomolecular Contrast Agents for Optical Coherence Tomography

This paper introduces gas vesicles as genetically encodable OCT contrast agents, enabling molecular and cellular imaging with OCT through differential refractive index and dynamic signal modulation.

Ultrasound Imaging of Gene Expression in Mammalian Cells

This paper introduces mammalian acoustic reporter genes that enable ultrasound imaging of gene expression in living animals.