Glioblastoma cell fate is differentially regulated by the microenvironments of the tumour bulk and infiltrative margin
C. Garcia-Diaz, E. Mereu, M. P. Clements, A. Pöysti, F. Galvez-Cancino, S. P. Castillo, L. Courtot, S. Ruiz, F. Roncaroli, Y. Yuan, S. A. Quezada, H. Heyn, S. Parrinello
This study compares glioblastoma cell fate in tumour bulk and margin, finding distinct neurogenic patterns and immune environments, with margin cells showing developmental-like trajectories and iNPCs linked to interferon signalling.
bioRxiv · Jun 11, 2021 · PreprintCancer Biology